Table 1.
T-Test P-values comparing DDR readouts between BRCA1 +/- vs. BRCA1 +/+ cell lines
|
Treatment |
AZD |
AZD |
AZD + TMZ |
AZD + TMZ |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Timepoint: |
48 h |
72 h |
48 h |
72 h |
||||||||
| Population: | All cells | Cyclin A2- | Cyclin A2+ | All cells | Cyclin A2- | Cyclin A2+ | All cells | Cyclin A2- | Cyclin A2+ | All cells | Cyclin A2- | Cyclin A2+ |
| Stain: |
|
|
|
|
|
|
|
|
|
|
|
|
| p-H2AX |
0.536 |
0.119 |
0.012 |
0.558 |
0.151 |
0.039 |
0.673 |
0.172 |
0.014 |
0.509 |
0.272 |
0.011 |
| p-RPA2 |
0.545 |
0.372 |
0.545 |
0.599 |
0.442 |
0.229 |
0.875 |
0.445 |
0.916 |
0.900 |
0.767 |
0.859 |
| p-DNA-PKcs |
0.398 |
0.419 |
0.957 |
0.597 |
0.469 |
0.336 |
0.776 |
0.952 |
0.894 |
0.758 |
0.562 |
0.297 |
| p21 |
0.315 |
0.413 |
0.132 |
0.645 |
0.737 |
0.203 |
0.693 |
0.708 |
0.364 |
0.778 |
0.706 |
0.452 |
| p-ATM |
0.636 |
0.848 |
0.390 |
0.940 |
0.693 |
0.228 |
0.746 |
0.967 |
0.736 |
0.813 |
0.920 |
0.694 |
| p-BRCA1 | 0.754 | 0.954 | 0.608 | 0.505 | 0.872 | 0.721 | 0.858 | 0.839 | 0.756 | 0.684 | 0.970 | 0.860 |
Statistically significant p-values (p < .05) for stratifying BRCA1+/- vs. BRCA1+/+cell lines are shown in bold.