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. 2014 May 7;57(11):4834–4848. doi: 10.1021/jm500361r

Scheme 2. ,

Scheme 2

Reagents and conditions: (a) R1NH2, AcOH; (b) Fe, NH4Cl, EtOH/H2O; (c) Cl3OCOCl, Et3N, DCM; (d) MeI, 0.15 M NaOH(aq), DCM, TBAB; (e) ArB(OH)2, Pd(PPh3)4, K2CO3, 1,2-DME, EtOH, H2O; (f) Pd(PPh3)4, K2CO3, 1,2-DME, EtOH, H2O.

See the tables for the R1 substituents.