Table 4. Comparison of Properties of 1 and Prioritized Compounds.

	1	4e	9	16e	16g
Potencies
T. brucei EC50 (μM)	0.0025	0.051	0.617	0.200	0.166
HepG2 TC50 (μM)	ndb	0.631	>50	4.786	11.220
LEc	0.32	0.30	0.33	0.33	0.32
mTOR IC50 (μM)	0.005	1.175	1.622	0.468	0.380
PI3Kα IC50 (μM)	0.020	0.398	3.981e	0.631	0.501
PI3Kβ IC50 (μM)	0.316	7.943	>30	31.623	7.943
PI3Kγ IC50 (μM)	0.100	0.126	1.995	0.251	0.316
PI3Kδ IC50 (μM)	0.013	0.794	15.849	2.512	2.512
Properties
MPO score	3.22	4.08	4.56	4.07	4.57
MW	469.6	422.5	342.4	366.4	382.4
cLogP	5.81	5.3	5.62	5.86	5.1
chromLogDd,21	4.75 (6.44)	(5.3)	(4.69)	3.5 (4.95)	3.03 (5.32)
TPSA	76.52	81.43	63.61	52.71	61.94
HBD	0	0	0	0	0
solubility (μM)22	19	nda	nda	17	22
permeability	nda	nda	570	470	860

^and = data not obtained.

^bNot obtained due to low solubility.

^cLE = −Log(pEC₅₀) × 1.37/number of heavy atoms.

^dLogD values in parentheses are calculated values.

^eOne replicate experiment showed an IC₅₀ >30 μM.