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. 2014 Jul 10;9:3313–3324. doi: 10.2147/IJN.S62793

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© 2014 Yao et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License

The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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Safety evaluation of HRA nanoparticles.

Notes: Hemolysis as a function of vehicle concentration of HRA conjugate and GA-HRA (n=3) (A); pathological section of vessel tissues (B); control (5% glucose solution) (a); combination of GA-ATRA-HA solution (b); HRA conjugate (c); GA-HRA (d).

Abbreviations: ATRA, all-trans retinoic acid; GA, gambogic acid; GA-HRA, GA-loaded HRA nanoparticles; HA, hyaluronic acid; HRA, hyaluronic acid-g-all-trans retinoic acid.