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. 2014 Jul 15;9(7):e102584. doi: 10.1371/journal.pone.0102584

Table 6. Diagnostic potential of individual markers detected in QFT-IT supernatants.

Markers TB cases (n = ) Non TB cases (n = ) P-value AUC (95% CI) Sensitivity, % (95% CI) Specificity, % (95% CI) Cut off value
VEGF Ag 100 (2–290) 120 (2–352) 0.085 67 (47–87) 79 (49–95) 60 (32–84) 117.0
CRPAg 188210 (3411–816000) 12918 (120–332914) 0.009 80 (62–95) 64 (49–95) 87 (27–78) 72307.0
SAAAg 579939 (560–4000000) 1115 (560–222320) 0.004 82 (66–98) 79 (49–95) 73 (45–92) 22752.0
SAPAg 48247 (24799–74998) 35242 (560–69282) 0.034 73 (54–93) 79 (49–95) 80 (52–96) 41205.0
MMP-9Ag 738806 (354239–700362629) 1435154 (278743–2444144) 0.073 72 (49–95) 71 (42–92) 67 (30–93) 935846.0
IP-10Ag-Nil 15799 (0–19426) 1773 (0–16430) 0.007 80 (65–97) 64 (57–98) 93 (32–84) 15696.0
MCP-1Ag-Nil 388 (0–7881) 0 (0–12922) 0.047 73 (52–91) 79 (49–95) 67 (38–88) –732.0
MCP-1Nil 9969 (1909–18125) 14912 (4368–20001) 0.015 77 (59–94) 60 (66–100) 93 (32–84) 14651.0
MIP-1β Nil 1096 (74–2258) 1792 (548–3190) 0.017 76 (59–93) 73 (42–92) 64 (32–84) 1334.0
TGF-α Nil 8 (2–39) 30 (2–144) 0.047 70 (50–90) 86 (57–98) 60 (32–83) 24.0
VEGF Nil 31 (2–626) 285 (2–727) 0.041 73 (51–91) 60 (49–95) 79 (32–84) 216.0
IL-10 Nil 8 (2–51) 41 (2–86) 0.032 74 (55–92) 80 (35–87) 64 (52–96) 11.0
IL-1β Nil 108 (2–365) 331 (17–1957) 0.050 72 (53–90) 67 (35–87) 84 (38–88) 254.0
CRP Nil 457028 (2831–816000) 35080 (157–816000) 0.032 78 (55–92) 64 (42–91) 80 (32–84) 66232.0
SAA Nil 1979000 (943–4160000) 1821 (560–173709) 0.002 84 (70–99) 64 (49–95) 100 (38–88) 176199.0
SAP Nil 44639 (23918–56777) 32733 (22470–79572.) 0.026 76 (55–94) 79 (49–95) 73 (45–92) 38751.0
MMP-9 Nil 617975 (275049–720100) 1347000 (331645–360500) 0.018 83 (60–100) 89 (49–95) 79 (51–100) 766037.0

Median levels (and ranges in parenthesis) of analytes detected in QFT-IT supernatants and accuracy in the diagnosis of TB disease. All analyte levels are in pg/ml except for CRP, SAA and SAP (ng/ml). P-values were calculated using the Mann Whitney U test. Cut-off values, sensitivity and specificity were selected based on the Youden’s index. AUC = Area under the receiver operator characteristics curve. 95% CI = 95% confidence interval. Nil = unstimulated marker levels, Ag = levels detected in antigen stimulated supernatants, Ag-N = Antigen specific marker levels obtained after subtraction of nil responses.