Table 1.
Descriptive characteristics in association studies on A218C/A779C TPH-1 gene variants and SB by populations
|
Reference |
Location |
Diagnosis |
Number of males |
Number |
Genotypes |
Alleles |
P for HWE |
|||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Cases |
Controls |
Cases |
Controls |
Cases |
Controls |
Cases |
Controls |
Cases |
Controls |
|||
| AA/AC/CC | AA/AC/CC | A/C | A/C | |||||||||
|
Caucasian population (A218C TPH-1 variant)
| ||||||||||||
| Bellivier F. et al., 1998 [62] |
France |
SA and manic-depression |
- |
57 |
104 |
94 |
34/48/22 |
11/45/38 |
116/92 |
67/121 |
0.08 |
0.55 |
| Geijer T. et al., 2000 [53] |
Sweden |
SA |
57 |
64 |
165 |
98 |
30/87/48 |
13/47/38 |
147/183 |
73/123 |
1.00 |
0.43 |
| Du L. et al., 2000 [54] |
Canada |
SC |
- |
- |
35 |
84 |
6/24/5 |
13/52/19 |
36/34 |
78/90 |
0.04* |
0.04* |
| Souery D. et al., 2001 [37] |
Germany, Greece, Israel, Italy, Sweden, UK. |
SI and bipolar disorder |
- |
- |
167 |
167 |
29/85/53 |
27/74/66 |
143/191 |
128/206 |
0.41 |
0.75 |
| Abbar M. et al., 2001 [47] |
France |
SA |
105 |
170 |
231 |
281 |
43/120/68 |
30/133/118 |
206/256 |
193/369 |
0.50 |
0.30 |
| Zalsman G.et al., 2001 [40] |
Israel |
SA |
40 |
74 |
84 |
172 |
16/34/34 |
41/85/46 |
66/102 |
167/178 |
0.89 |
0.17 |
| Turecki G. et al., 2001 [39] |
Canada |
SC |
- |
- |
101 |
129 |
18/48/35 |
18/71/40 |
84/118 |
107/151 |
0.15 |
0.83 |
| Rujescu D. et al., 2002 [36] |
Germany |
SA and anger related traits |
27 |
66 |
86 |
154 |
10/48/28 |
19/78/57 |
68/104 |
116/192 |
0.39 |
0.17 |
| Rujescu D. et al., 2003 [24] |
Germany |
SA |
52 |
- |
147 |
326 |
18/81/48 |
40/155/131 |
117/177 |
235/417 |
0.63 |
0.08 |
| Jernej B. et al., 2004 [34] |
Croatia |
SC |
144 |
298 |
185 |
358 |
84/85/16 |
202/141/15 |
253/117 |
545/171 |
0.14 |
0.49 |
| Stefulj J. et al., 2005 [16] |
Croatia |
SC |
160 |
284 |
160 |
284 |
21/69/70 |
44/145/95 |
111/209 |
233/335 |
0.39 |
0.60 |
| Stefulj J. et al., 2006 [46] |
Croatia |
SC |
247 |
320 |
247 |
320 |
33/111/103 |
50/162/108 |
177/317 |
262/378 |
0.48 |
0.78 |
| Viana M.M. et al., 2006 [48] |
Brazil |
SA, major depression, schizophrenia and alcoholism |
142 |
36 |
248 |
63 |
45/125/78 |
7/31/25 |
215/281 |
45/81 |
0.78 |
0.79 |
| Baud P. et al., 2009 [28] |
Switzerland, France |
SA |
166 |
- |
537 |
1027 |
99/256/182 |
181/483/363 |
454/260 |
845/1209 |
0.59 |
0.34 |
| Wilson T.et al., 2009 [52] |
USA |
SA and bipolar disorder |
- |
39 |
71 |
101 |
13/44/14 |
22/43/36 |
70/72 |
87/115 |
0.22 |
0.05* |
| Saetre P. et al., 2010 [23] |
Denmark, Norway, Sweden |
SA and schizophrenia |
- |
845 |
825 |
1460 |
289/391/145 |
570/694/196 |
969/681 |
1834/1086 |
0.00* |
0.63 |
| Buttenschon H.N. et al., 2013 [41] |
Denmark |
SC |
209 |
763 |
490 |
1027 |
80/228/182 |
181/843/363 |
388/592 |
845/1209 |
0.36 |
0.57 |
| |
|
|
|
|
|
|
868/1884/1131 |
1469/3282/1754 |
|
|
0.11 |
0.37 |
|
Asian population (A218C TPH-1 variant)
| ||||||||||||
| Tsai S.J. et al., 1999 [55] |
Taiwan |
SA and mood disorders |
- |
- |
41 |
200 |
17/15/9 |
33/113/54 |
49/33 |
179/221 |
0.06 |
0.19 |
| Liu X. et al., 2006 [56] |
China |
SA |
171 |
98 |
287 |
177 |
72/148/67 |
41/84/49 |
292/282 |
166/182 |
0.65 |
0.63 |
| Yoon H.K. et al., 2008 [44] |
Korea |
SA and major depression |
70 |
73 |
193 |
191 |
49/97/45 |
60/85/48 |
195/187 |
205/181 |
0.11 |
0.88 |
| Kunugi H. et al.,1999 [42] |
Japan |
SA |
- |
95 |
46 |
208 |
10/29/7 |
55/105/48 |
49/43 |
215/201 |
1.00 |
0.13 |
| Paik I. et al., 2000 [45] |
Korea |
SA and schizophrenia |
- |
124 |
27 |
236 |
04/12/11 |
66/116/54 |
20/34 |
248/224 |
0.89 |
1.00 |
| Ono H., et al., 2000 [43] |
Japan |
SC |
90 |
90 |
132 |
132 |
29/68/35 |
26/71/35 |
126/138 |
123/141 |
0.38 |
0.86 |
| Hong C.J. et al., 2001 [35] |
Taiwan |
SA and schizophrenia |
- |
123 |
140 |
251 |
42/57/41 |
42/135/74 |
141/139 |
219/283 |
0.15 |
0.02* |
| Ohtani M. et al., 2004 [49] |
Japan |
SC |
95 |
171 |
134 |
325 |
30/60/42 |
44/113/57 |
120/144 |
201/227 |
0.41 |
0.37 |
| |
|
|
|
|
|
|
253/486/257 |
367/822/419 |
|
|
|
|
|
Caucasian population (A779C TPH-1 variant)
| ||||||||||||
| Nielsen D.A. et al.,1998 [38] |
USA |
SI and alcoholism |
- |
232 |
102 |
232 |
17/57/28 |
49/106/77 |
91/113 |
204/260 |
0.28 |
0.23 |
| Rotondo A. et al., 1999 [51] |
Italy and USA |
SA |
- |
153 |
97 |
153 |
12/50/35 |
33/68/52 |
74/120 |
215/201 |
0.25 |
0.51 |
| Roy A. et al., 2001 [17] |
Sweden |
SC |
- |
- |
24 |
158 |
02/12/20 |
35/86/37 |
16/332 |
156/160 |
0.33 |
1.00 |
| Saetre P. et al., 2010 [23] |
Denmark, Norway and Sweden |
SA and schizophrenia |
- |
845 |
830 |
1464 |
290/391/149 |
570/691/203 |
971/689 |
1831/1097 |
0.00* |
0.63 |
| Pooley E.C. et al., 2003 [50] |
UK |
SA |
52 |
138 |
129 |
329 |
20/67/42 |
44/135/150 |
107/151 |
223/435 |
0.13 |
0.47 |
| |
|
|
|
|
|
|
341/577/274 |
731/1086/519 |
|
|
0.44 |
0.34 |
|
Asian population (A779C TPH-1 variant)
| ||||||||||||
| Kunugi H. et al., 1999 [42] |
Japan |
SA |
- |
95 |
46 |
208 |
10/29/7 |
55/105/48 |
49/43 |
215/201 |
1.00 |
0.13 |
| Ohtani M. et al., 2004 [49] |
Japan |
SC |
95 |
171 |
134 |
325 |
30/59/42 |
45/138/82 |
119/143 |
228/302 |
0.38 |
0.29 |
| Liu X., et al. 2006 [56] |
China |
SA |
171 |
98 |
266 |
164 |
77/126/63 |
43/85/36 |
280/252 |
171/157 |
0.75 |
0.46 |
| 117/214/112 | 143/328/166 | 0.50 | 0.47 | |||||||||
SA = Suicide attempt, SI = Suicide ideation, and SC = Suicide completion.* Non equilibrium of Hardy Weinberg.