Table 2. Recognition of diverse classes of antimicrobial peptides by the enantiomeric sequence formulae.
| Sequence isoform, no. found
|
||||||
|---|---|---|---|---|---|---|
| Antimicrobial peptide class | Phylogeny | Dextro | Levo-1 | Levo-2 | Total | % of total |
| α-Defensin | Chordata | 24 | 42 | 6 | 72 | 15.3 |
| β-Defensin | Chordata | 52 | 65 | 31 | 148 | 31.4 |
| θ-Defensin | Chordata | 1 | 1 | 0 | 2 | 0.4 |
| Insect defensin/CS-αβ | Insectae | 21 | 23 | 12 | 56 | 11.9 |
| Plant defensin/CS-αβ | Plantae | 51 | 67 | 20 | 138 | 29.3 |
| Invertebrate defensin/CS-αβ | Mollusca | 3 | 4 | 4 | 11 | 2.3 |
| Protegrins/gomesins | Chordata/Arthropoda | 0 | 0 | 6 | 6 | 1.3 |
| Tachyplesins/Polyphemusins | Arthropoda | 6 | 5 | 2 | 13 | 2.8 |
| Thanatin | Arthropoda | 0 | 1 | 0 | 1 | 0.2 |
| Mytilins/Big Defensin | Mollusca | 3 | 3 | 2 | 8 | 1.7 |
| AFP-1 | Ascomycota | 1 | 0 | 0 | 1 | 0.2 |
| Lantibiotics/microcins | Proteobacteria | 3 | 3 | 9 | 15 | 3.2 |
| Total | 165 | 214 | 92 | 471 | ||
Forward or reverse Swiss-Prot databases (release 42.4; November 14, 2003; 138,347 entries) were probed with formulae containing the dextromeric or levomeric motifs of the antimicrobial peptide signature by using prosite (14). Data indicate the proportionate distribution of a nonredundant cohort of retrieval sets; in some cases, peptides were retrieved by more than one formula isoform. Note that search results include members of the lantibiotic superfamily of antimicrobial peptides, which lack conventional disulfide bridges but have thioether stabilization.