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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biochim Biophys Acta. 2014 Mar 12;1839(8):627–643. doi: 10.1016/j.bbagrm.2014.03.001

Figure 1. Writing, erasing, and reading the histone and DNA modification landscape.

Figure 1

Isolated and linked protein domains coordinate the addition (writing), removal (erasing), and association (reading) of DNA modifications (black circles) and histone PTMs (blue circles and red triangles), creating a dynamic and variable chromatin environment. Cis refers to multivalent events occurring on the same histone. Trans refers to multivalent events occurring on adjacent histones or spanning histones and DNA, either within the same nucleosome or on neighboring nucleosomes. Trans interactionswith distant nucleosomes (which may be in 3-dimensional proximity) are not depicted. Multivalent interactions facilitated by membership in macromolecular complexes are also not depicted.