Table 3.

Risk factors for hemorrhagic cystitis.

Factor		Hazard Ratio (95% CI)	P Value
Age (years)	1 year increment	1.07 (1.02,1.12)	.003
Female	ref: male	0.36 (0.08,1.62)	.185
KGF	ref: no	0.23 (0.03,1.88)	.170
Serum BKV IgG titer	4 fold increment	1.06 (0.72,1.55)	.779
Mismatched donor	ref: matcheda	1.04 (0.30,3.63)	.956
T-cell depletion (TCD)	ref: non-TCD	0.58 (0.17,2.01)	.387
Stem cell source Cord blood	ref: Peripheral blood	2.22 (0.56,8.84)	.259
aGVHD grade 2-4*	ref: aGVHD grade 0-1	3.46 (0.63, 19.02)	.153
Ciprofloxacin use	ref=no	0.18 (0.02,1.34)	.094
Pre-HSCT urine BKV ≥ 1.0×107 copies/mL	ref < 1.0×107	9.01 (2.61,31.08)	.001
Post-HSCT urine BKV ≥ 1.0×107 copies/mL*	ref < 1.0×107	9.07 (1.67, 49.16)	.011
MA or RIC	ref: NMA	1.51 (0.21, 10.80)	.680
Total body irradiation	ref: no	0.60 (0.16, 2.27)	.450
CMX001 treatment*	ref: no	2.96 (0.35, 25.09)	.316
Foscarnet treatment*	ref: no	20.20 (4.18, 97.66)	<.001
CMV seropositive recipient	ref: seronegative	1.43 (0.37, 5.52)	.600
CMV reactivation*	ref: no	6.36 (1.22, 33.09)	.028

Abbreviations: HSCT, hematopoietic stem cell transplantation; KGF, keratinocyte growth factor; TCD, T-cell depletion; aGVHD, acute graft versus host disease; MA, myeloablative; RIC, reduced intensity; NMA, nonmyeloablative; TBI, total body irradiation; CMV, cytomegalovirus; ref, reference

^aMatched donor included matched related donor and matched unrelated donor.

^*The post-transplant factor was examined as a time-dependent variable in cause-specific Cox regression.