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. Author manuscript; available in PMC: 2015 Aug 22.
Published in final edited form as: Neuroscience. 2014 May 27;274:138–152. doi: 10.1016/j.neuroscience.2014.05.031

Fig. 9.

Fig. 9

A769662 shortens plateau potentials by activating K-ATP. Current-clamp whole-cell recordings of plateau potentials obtained from STN neurons without (control) and with A769662 in pipettes. Although NMDA lengthened the plateau potential under control conditions (A), NMDA shortened the plateau potential when recording with a pipette that contained A769662 (B). Both tolbutamide (C) and dorsomorphin (D) blocked the effect of A769662, thus allowing NMDA to lengthen the plateau potential. Each plateau potential was evoked by a brief depolarizing current pulse (200 pA; 100 ms duration) as illustrated under the voltage trace in “D”. A holding current was applied to establish an initial membrane potential of −70 mV. Wash indicates recording after NMDA is washed from the slice. Data were obtained from four different neurons.