. Author manuscript; available in PMC: 2016 Apr 1.

Published in final edited form as: J Intensive Care Med. 2014 Jan 8;30(7):401–412. doi: 10.1177/0885066613517076

Table 4B.

Comparison of predictive values of ferritin and sIL-2 R testing in HLH

FERRITIN
>500 ug/L	100% sensitivity, 80 specificity for diagnosis of HLH^(a)
>10,000 ug/L	90% sensitivity, 96% specificity for diagnosis of HLH^(b)
ferritin decrease <50%	odds ratio of death 17.42 compared to ferritin decrease >96%^(c)
>11,000 in the first 3 weeks	odds ratio of death 5.6 compared to ferritin <11,000 in the first 3 weeks^(c)
SOLUBLE IL-2 RECEPTOR
> 2400 (2SD above mean)	93% sensitivity for diagnosis of HLH^(d)
<10,000	78% survival^(e)
>10,000	35% survival^(e)

^(a)

Based on Henter JI et al. Pediatr Blood Cancer. 2007;48(2):124-31

^(b)

Allen CE et al. Pediatr Blood Cancer. 2008;50(6):1227-35

^(c)

Lin TF et al. Pediatr Blood Cancer. 2011;56(1):154-5

^(d)

Komp Dm et al. Blood. 1989;73(8):2128-32

^(e)

Imashuku S et al. Blood. 1995;86(12):4706-7.