Figure 6. Ryk is colocalized with human SOD1 protein in motor neurons and in the white matter of SOD1-G93A mouse lumbar spinal cord but not in extracellular aggregates.
A, Immunostaining of coronal sections of lumbar spinal cords of P120 SOD1 (G93A) mice for Ryk (green), human SOD1 (red) and ChAT (blue). Ryk is colocalized with human SOD1 protein in ChAT+ motor neurons (arrows) in the ventral lumbar spinal cord of P120 SOD1 (G93A) mice. B, Colocalization of Ryk expression with human SOD1 protein in the white matter of the ventral spinal cord of P120 SOD1 (G93A mice). Scales bars: 25 µm (A), 100 µm (B).
