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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Biol Blood Marrow Transplant. 2014 Apr 13;20(8):1121–1129. doi: 10.1016/j.bbmt.2014.03.032

Figure 1.

Figure 1

Final pharmacokinetic model characterizing total MPA, unbound MPA, and total MPAG concentrations following oral MMF administration. tlag = lag time; GI = gastrointestinal tract; ka = first-order absorption rate constant; fu= fraction unbound of MPA; Vc = volume of central compartment of total MPA; Q = inter-compartment clearance of total MPA; Vp = volume of peripheral compartment of total MPA; CLMPA = clearance of total MPA; CLtotal MPAG = clearance of total MPAG; Vm = volume of central compartment of total MPAG; k41 = first-order rate constant of enterohepatic recirculation (EHC).