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. 2014 Jun 30;20(2):218–222. doi: 10.3350/cmh.2014.20.2.218

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Copyright © 2014 by The Korean Association for the Study of the Liver

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Changes of DWI and ADC values following Sorafenib treatment in a 57-year-old woman with HCC. (A) On DWI with high b-value of 1,000 before treatment, two high signal tumors are noted in S8 and S4 (arrows). (B) An ADC map before treatment shows low signal intensity lesions at the same area (arrows), which means low ADC values. (C) After 4-month treatment with Sorafenib, signal intensity of HCC (arrows) on DWI with b-value of 1,000 was markedly decreased compared to (A). (D) An ADC map after Sorafenib treatment also shows improved diffusion with higher signal (arrows). (E) Axial, enhanced, portal venous phase image after Sorafenib treatment shows marked necrosis of tumors, which is the cause of increased ADC values and lower signal intensity on DWI.