Figure 5. Metformin reduces BACE1 protein levels in vivo.

Wild type mice were treated for 2 weeks with 5/l metformin in the drinking water (≈0.03 M). Brain lysates of these mice were analyzed on western blots detecting BACE1, pS6, total S6, GAPDH and β-actin. Bars represent mean values +/− SEM, (n = 5 per group, *p<0.05).