Table 2.
Effects of the standardized extract from M. urundeuva (SEMU) on striatal DA and DOPAC levels (ng/g tissue), in the model of Parkinson's disease in rats.
| Group | Dopamine (DA) | DOPAC | DOPAC/DA |
|---|---|---|---|
| 6-OHDA ipsilateral |
881.5 ± 108.77a | 825.6 ± 121.2 | 0.94 |
| 6-OHDA contralateral |
2559.0 ± 149.0 | 1141.0 ± 120.1 | 0.45 |
| SEMU 10 ipsilateral |
1057.0 ± 42.3 | 831.30 ± 239.8 | 0.79 |
| SEMU 10 contralateral |
2021.0 ± 37.57 | 1299.0 ± 167.1 | 0.64 |
| SEMU 20 ipsilateral |
1913.0 ± 146.2 | 208.2 ± 36.2a,b | 0.11 |
| SEMU 20 contralateral |
2582.0 ± 280.2b | 304.6 ± 46.6 | 0.12 |
| SEMU 40 ipsilateral |
2450.0 ± 1637a,b | 314.7 ± 12.6a | 0.13 |
| SEMU 40 contralateral |
3921.0 ± 221.8 | 1755.0 ± 172.0 | 0.45 |
| SO ipsilateral |
3186.0 ± 285.3b | 1556.0 ± 227.7b | 0.49 |
| SO contralateral |
2942.0 ± 204.0 | 1746.0 ± 196.6 | 0.59 |
The standardized extract from M. urundeuva (SEMU: 5, 10, 20, and 40 mg/kg, p.o.) was administered 1 h after the stereotaxic surgery (injection of 6-OHDA or distilled water into the right striatum-SO) and, afterwards, daily for 14 days. After behavioral experiments, all animals were euthanized for the dissection of right and left striata. The results are means ± SEM from 5 to 12 animals. a,b P < 0.05 versus the contralateral side of each group or versus the SO group (one-way ANOVA and the Newman-Keuls as the post hoc test).