Table 4. Haplotype distribution and their association analysis with drug response in schizophrenia patients (n = 423).
| Groups | Gene | SNPs | Haplotype | Number (frequency) | OR (95%CI) | P-value | |
| CR | IR | ||||||
| Low Severity | SLC6A3 | rs6347|rs2550956 | AT | 47 (0.17) | 27 (0.26) | 1.91 (0.05–3.43) | 0.021 |
| AC | 196 (0.69) | 59 (0.59) | 0.52 (0.29–0.96) | 0.021 | |||
| PIP4K2A | rs746203|rs10828317|rs7094131|rs2296624|rs11013052|rs1409396 | GCCAAC | 32 (0.12) | 14 (0.14) | 1.12 (0.52–2.31) | 0.742 | |
| ATTGCC | 46 (0.17) | 14 (0.14) | 0.72 (0.34–1.43) | 0.327 | |||
| ATTGCT | 136 (0.5) | 57 (0.56) | 1.17 (0.67–2.07) | 0.567 | |||
| High Severity | SLC6A3 | rs6347|rs2550956 | AT | 21 (0.17) | 86 (0.27) | 1.73 (0.99–3.14) | 0.044 |
| AC | 86 (0.61) | 203 (0.61) | 0.58 (0.32–1.01) | 0.044 | |||
| PIP4K2A | rs746203|rs10828317|rs7094131|rs2296624|rs11013052|rs1409396 | GCCAAC | 25 (0.2) | 46 (0.15) | 0.62 (0.34–1.13) | 0.091 | |
| ATTGCC | 26 (0.21) | 43 (0.13) | 0.55 (0.31–0.99) | 0.029 | |||
| ATTGCT | 53 (0.44) | 190 (0.64) | 2.05 (1.26–3.33) | 0.002a | |||
Footnote: SNPs with P<0.05 were included for haplotype analysis, Haplotype with minimum frequency less than 0.10 were excluded from the study,
a
P-values less than threshold value of α which is equal to 0.05/18(n) = 0.0027, where n is number of test for haplotype association analysis.
CR, Complete responders; IR, Incomplete responders; OR, Odds ratio; CI, Confidence interval.