Table 6. Distribution of diplotype, ATTGCT/ATTGCT (PIP4K2A) and its association analysis with drug response in schizophrenia patients (n = 423), atypical monotherapy (n = 355) and risperidone group (n = 260).
| Groups | SNPs | Number (frequency) | OR (95%CI) | P-value | |
| CR | IR | ||||
| Schizophrenia patients | |||||
| Low severity | rs746203|rs10828317|rs7094131|rs2296624|rs11013052|rs1409396 | 33 (0.67) | 16 (0.32) | 1.51 (0.69–3.22) | 0.252 |
| High severity | rs746203|rs10828317|rs7094131|rs2296624|rs11013052|rs1409396 | 9 (0.14) | 55 (0.85) | 3.37 (1.51–8.28) | 0.001a |
| Atypical monotherapy group | |||||
| Low severity | rs746203|rs10828317|rs7094131|rs2296624|rs11013052|rs1409396 | 28 (0.68) | 13 (0.31) | 1.34 (0.57–3.04) | 0.458 |
| High severity | rs746203|rs10828317|rs7094131|rs2296624|rs11013052|rs1409396 | 7 (0.14) | 43 (0.86) | 3.6 (1.45–10.15) | 0.002a |
| Risperidone group | |||||
| Low severity | rs746203|rs10828317|rs7094131|rs2296624|rs11013052|rs1409396 | 16 (0.59) | 11 (0.40) | 1.83 (0.66–4.90) | 0.18 |
| High severity | rs746203|rs10828317|rs7094131|rs2296624|rs11013052|rs1409396 | 4 (0.10) | 35 (0.89) | 5.09 (1.62–21.01) | 0.002a |
Footnote: Haplotype withstand Bonferonni correction was included for diplotype analysis. Diplotype with minimum frequency less than 0.10 were ignored.
a
P-values less than threshold value of α which is equal to 0.05/6(n) = 0.008, where n is number of test for diplotype association analysis.
CR, Complete responders; IR, Incomplete responders; OR, Odds ratio; CI, Confidence interval.