Table 7. Multivariate logistic regression analysis with incomplete antipsychotic response in schizophrenia patients stratified by treatment.
Schizophrenia patients (n = 423) | Atypical monotherapy group (n = 355) | Risperidone group (n = 260) | ||||||||||
Variables | Low severity | High severity | Low severity | High severity | Low severity | High severity | ||||||
OR (95% CI) | P -value | OR (95% CI) | P -value | OR (95% CI) | P -value | OR (95% CI) | P -value | OR (95% CI) | P -value | OR (95% CI) | P -value | |
Diplotype (ATTGCT/ATTGCT) | 1.41(0.67–2.97) | 0.366 | 3.19(1.46–6.98) | 0.004b | 1.23(0.54–2.77) | 0.623 | 3.66(1.51–8.88) | 0.004b | 1.95(0.71–5.36) | 0.193 | 4.75(1.53–14.72) | 0.007b |
Sex (female) | 1.04(0.53–2.06) | 0.903 | 1.2(0.65–2.24) | 0.548 | 1.01(0.49–2.11) | 0.971 | 1.18(0.59–2.33) | 0.635 | 1.17(0.48–2.89) | 0.724 | 1.48(0.67–3.25) | 0.322 |
Duration of illness (long) | 2.02(0.93–4.41) | 0.078 | 1.93(0.99–3.74) | 0.052 | 1.98(0.86–4.54) | 0.107 | 1.92(0.90–4.08) | 0.090 | 1.68(0.61–4.65) | 0.317 | 1.79(0.73–4.39) | 0.206 |
Age at onset (late) | 2.58(0.83–8.02) | 0.101 | 0.74(0.29–1.83) | 0.511 | 2.97(0.88–10.01) | 0.079 | 0.54(0.19–1.56) | 0.255 | 3.93(0.98–15.77) | 0.053 | 0.59(0.17–2.01) | 0.395 |
Age a | 1.08(0.83–8.03) | 0.046b | 0.97(0.91–1.04) | 0.381 | 1.09(1.00–1.19) | 0.033 | 0.96(0.89–1.03) | 0.261 | 1.14(1.03–1.26) | 0.011b | 0.96(0.88–1.04) | 0.345 |
Nagelkerke’s R2 | 2.98% | 6.22% | 3.21% | 7.47% | 7.07% | 8.98% | ||||||
Sensitivity | 1 | 0.61 | 1 | 0.67 | 0.98 | 0.73 | ||||||
Specificity | 0 | 0.62 | 0 | 0.61 | 0 | 0.60 | ||||||
Positive Predictive Value | 0.74 | 0.40 | 0.73 | 0.43 | 0.70 | 0.42 | ||||||
Negative Predictive Value | 0 | 0.80 | 0 | 0.81 | 0 | 0.84 | ||||||
Correctly classified | 0.74 | 0.62 | 0.73 | 0.63 | 0.69 | 0.64 | ||||||
ROC area (SE; 95%CI) | 0.54 (0.04; 0.46 – 0.61) | 0.60 (0.03; 0.55–0.66) | 0.53 (0.04; 0.45–0.60) | 0.61 (0.03; 0.55–0.67) | 0.56 (0.05; 0.47–0.65) | 0.63 (0.03; 0.56–0.69) |
Footnote- OR, Odds ratio; ROC, Receiver operating characteristic; SE, Standard error; CI, Confidence interval.
Taken as continuous variable.
Significant p-value.