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. 2014 Jul 15;9(7):e102556. doi: 10.1371/journal.pone.0102556

Table 7. Multivariate logistic regression analysis with incomplete antipsychotic response in schizophrenia patients stratified by treatment.

Schizophrenia patients (n = 423) Atypical monotherapy group (n = 355) Risperidone group (n = 260)
Variables Low severity High severity Low severity High severity Low severity High severity
OR (95% CI) P -value OR (95% CI) P -value OR (95% CI) P -value OR (95% CI) P -value OR (95% CI) P -value OR (95% CI) P -value
Diplotype (ATTGCT/ATTGCT) 1.41(0.67–2.97) 0.366 3.19(1.46–6.98) 0.004b 1.23(0.54–2.77) 0.623 3.66(1.51–8.88) 0.004b 1.95(0.71–5.36) 0.193 4.75(1.53–14.72) 0.007b
Sex (female) 1.04(0.53–2.06) 0.903 1.2(0.65–2.24) 0.548 1.01(0.49–2.11) 0.971 1.18(0.59–2.33) 0.635 1.17(0.48–2.89) 0.724 1.48(0.67–3.25) 0.322
Duration of illness (long) 2.02(0.93–4.41) 0.078 1.93(0.99–3.74) 0.052 1.98(0.86–4.54) 0.107 1.92(0.90–4.08) 0.090 1.68(0.61–4.65) 0.317 1.79(0.73–4.39) 0.206
Age at onset (late) 2.58(0.83–8.02) 0.101 0.74(0.29–1.83) 0.511 2.97(0.88–10.01) 0.079 0.54(0.19–1.56) 0.255 3.93(0.98–15.77) 0.053 0.59(0.17–2.01) 0.395
Age a 1.08(0.83–8.03) 0.046b 0.97(0.91–1.04) 0.381 1.09(1.00–1.19) 0.033 0.96(0.89–1.03) 0.261 1.14(1.03–1.26) 0.011b 0.96(0.88–1.04) 0.345
Nagelkerke’s R2 2.98% 6.22% 3.21% 7.47% 7.07% 8.98%
Sensitivity 1 0.61 1 0.67 0.98 0.73
Specificity 0 0.62 0 0.61 0 0.60
Positive Predictive Value 0.74 0.40 0.73 0.43 0.70 0.42
Negative Predictive Value 0 0.80 0 0.81 0 0.84
Correctly classified 0.74 0.62 0.73 0.63 0.69 0.64
ROC area (SE; 95%CI) 0.54 (0.04; 0.46 – 0.61) 0.60 (0.03; 0.55–0.66) 0.53 (0.04; 0.45–0.60) 0.61 (0.03; 0.55–0.67) 0.56 (0.05; 0.47–0.65) 0.63 (0.03; 0.56–0.69)

Footnote- OR, Odds ratio; ROC, Receiver operating characteristic; SE, Standard error; CI, Confidence interval.

a

Taken as continuous variable.

b

Significant p-value.