Table 1. Summary results.
For each variable, outcome and subgroup of interest, the hazard ratio is given along with its associated 95% confidence interval and p value.
Population | Outcome | Variable | HR (95CI, p value) |
---|---|---|---|
Overall cohort | Overall Survival | LIC>5 mg/gdw LIC>7 mg/gdw SF > 1000 ng/ml SF > 2500 ng/ml |
1.0 (0.6–1.5), p=1.0 1.4 (0.9–2.3), p=0.2 1.7 (1.0–2.7), p=0.036 1.3 (0.8–2.0), p=0.3 |
Non-relapse mortality | LIC>5 mg/gdw LIC>7 mg/gdw SF > 1000 ng/ml SF > 2500 ng/ml |
1.0 (0.6–1.7), p=0.9 1.7 (0.9–3.3), p=0.09 1.6 (0.9–2.8), p=0.14 1.4 (0.8–2.3), p=0.3 |
|
MAC cohort | Overall Survival | LIC>7 mg/gdw SF > 1000 ng/ml |
1.3 (0.4–4.4), p=0.6 1.5 (0.6–3.5), p=0.4 |
Non-relapse mortality | LIC>7 mg/gdw SF > 1000 ng/ml |
Not evaluableb | |
RIC cohorta | Overall Survival | LIC>7 mg/gdw SF > 1000 ng/ml |
1.5 (0.8–2.7), p=0.2 1.5 (0.8–2.8), p=0.2 |
Non-relapse mortality | LIC>7 mg/gdw SF > 1000 ng/ml |
2.2 (1.1–4.6), p=0.026a 1.5 (0.7–3.3), p=0.3 |
|
Acute leukemia + MDS | Overall Survival | LIC>7 mg/gdw SF > 1000 ng/ml |
1.2 (0.7–2.3), p=0.6 1.5 (0.7–3.1), p=0.3 |
Non-relapse mortality | LIC>7 mg/gdw SF > 1000 ng/ml |
1.5 (0.7–3.0), p=0.3 1.1 (0.6–2.2), p=0.7 |
HR denotes hazard ratio; 95CI, 95% confidence interval; LIC, liver iron content; SF, serum ferritin; MAC, myeloablative conditioning; RIC, reduced intensity conditioning; MDS, myelodysplastic syndromes.
See text for comment
Due to the small number of events in this subgroup.