Fig. 6.

Water conservation and urinary concentrating ability of UT-A1/3^-/- mice. For all graphs, values are mean ± SE. ^*, Significant difference between wild-type (filled bars) and UT-A1/3^-/- (open bars) mice. (A) Values obtained when mice received a 20% protein diet. (B) Identical studies performed on a 4% protein diet. Graphs show 24-h water consumption, urine output under basal conditions (free access to drinking water), urine osmolality under basal conditions, urine output after a 24-h water restriction, and maximal urinary osmolality after a 24-h water restriction.