Table 1.

Analysis of simple and putative layer IV cells in nob V1

	All Cells		Simple Cells		Putative Layer IV Cells
Property	WT	nob	WT	nob	WT	nob
OSI	0.84 ± 0.07 (n = 66)	0.57 ± 0.04* (n = 97)	0.90 ± 0.06 (n = 54)	0.59 ± 0.05‡ (n = 71)	0.86 ± 0.10 (n = 33)	0.44 ± 0.06† (n = 46)
gOSI	0.54 ± 0.06 (n = 66)	0.33 ± 0.03‡ (n = 97)	0.62 ± 0.06 (n = 54)	0.34 ± 0.04‡ (n = 71)	0.62 ± 0.09 (n = 33)	0.26 ± 0.04‡ (n = 46)
Pref response, spikes/s	6.8 ± 0.8 (n = 66)	4.5 ± 0.3† (n = 97)	5.70 ± 0.81 (n = 54)	4.30 ± 0.34* (n = 71)	7.50 ± 1.04 (n = 33)	4.40 ± 0.48* (n = 46)
Null response, spikes/s	0.08 ± 0.05 (n = 66)	0.40 ± 0.09* (n = 97)	0.00 ± 0.04 (n = 54)	0.27 ± 0.08† (n = 71)	0.02 ± 0.09 (n = 33)	0.53 ± 0.19* (n = 46)
Half-saturation contrast c50, %	30.2 ± 6.8 (n = 20)	59.7 ± 4.7‡ (n = 34)	30.1 ± 7.3 (n = 19)	56.3 ± 5.9‡ (n = 27)	28.8 ± 12.1 (n = 11)	56.3 ± 9.7† (n = 14)
Slope of contrast response curve	2.18 ± 0.22 (n = 20)	1.33 ± 0.11‡ (n = 34)	1.84 ± 0.23 (n = 19)	0.99 ± 0.11‡ (n = 27)	1.97 ± 0.29 (n = 11)	1.02 ± 0.15† (n = 14)
Fano factor: low contrast	–	–	0.70 ± 0.06 (n = 70)	1.33 ± 0.10‡ (n = 66)	0.63 ± 0.12§ (n = 27)	1.29 ± 0.20‡§ (n = 26)
Fano factor: high contrast	–	–	0.47 ± 0.05 (n = 70)	0.88 ± 0.06‡ (n = 66)	0.40 ± 0.10§ (n = 27)	0.80 ± 0.10‡§ (n = 26)

Values are means ± SE. All statistical comparisons are made between wild-type (WT) and nob groups. gOSI, global orientation selectivity index.

^*P < 0.05;

^†P < 0.01;

^‡P < 0.001;

^§Fano factor for layer IV simple cells only.