Table 1.
Top ten single nucleotide polymorphism (SNP) markers significantly (chromosome-wise false discovery rate < 0.05) associated with antibody-mediated immune response in Holstein cows and genes within 250,000 base pairs flanking the markers
| BTA | SNP | Location (bp) | -log 10 P | Entrez gene ID |
|---|---|---|---|---|
| 23 | ARS-BFGL-NGS-111879 | 25,109,188 | 15.95 | BolA-DQA1, ELOVL5, FBXO9, GCM1, GSTA3, GSTA4, GSTA5, ICK |
| 23 | Hapmap50029-BTA-55899 | 24,181,053 | 13.10 | IL17A, IL17F, MIR133B, MIR206 |
| 23 | BTA-27247-no-rs | 26,736,263 | 12.49 | BTN3A2, NOTCH4, TSBP |
| 23 | ARS-BFGL-NGS-105563 | 28,819,118 | 9.91 | GABBR1, MOG, PPP1R11, TRIM10, TRIM15, TRIM26, TRIM31, TRIM40, UBD, ZNRD1 |
| 23 | ARS-BFGL-BAC-3611 | 33,645,739 | 9.70 | - |
| 23 | Hapmap57845-rs29014813 | 32,998,188 | 9.69 | ACOT13, ALDH5A1, FAM65B, GMNN, GPLD1, MRS2, TDP2 |
| 23 | Hapmap44002-BTA-110636 | 25,178,791 | 9.01 | BOLA-DQA1, BOLA-DQB, ELOVL5, FBXO9, GCM1, GSTA3, GSTA4, ICK |
| 23 | BTA-55821-no-rs | 27,944,066 | 8.98 | ATAT1, BOLA, CCHCR1, CDSN, DDR1, DHX16, FLOT1, GTF2H4, IER3, KIAA1949, MDC1, MICB, MRPS18B, NRM, POU5F1, PPP1R10, PSORS1C2, SFTA2, TCF19, TUBB |
| 23 | ARS-BFGL-NGS-37272 | 32,025,158 | 8.78 | HIST1H2BA, LRRC16A, SCGN, SLC17A1, SLC17A3, SLC17A4 |
| 23 | Hapmap41584-BTA-56031 | 24,939,249 | 8.20 | ELOVL5, FBXO9, GCM1, GSTA1, GSTA3, GSTA3, GSTA4, GSTA5, ICK, TMEM14A, TRAM2 |