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. 2014 Jul 7;14:489. doi: 10.1186/1471-2407-14-489

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Copyright © 2014 Chen et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Bioinformatic analysis of target genes of the four miRNAs. (A) The network of target genes of the four miRNAs involved in Tregs functions. Each ellipse represented a target gene predicted by TargetScan. The four rhombuses were miRNAs and the triangle was the MeSH term of Tregs. Purple lines indicated genes involved in Tregs according to MeSH database; magenta lines outlined the miRNAs-target genes relations. (B) Pathway enrichment of target genes. The y-axis represented pathways enriched based on predicted target genes of the four miRNAs. The histogram indicated gene number in each pathway (upper black x-axis); the curve line indicated the P value (lower blue x-axis). **P < 0.01 with the Bonferroni correction.