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. 2014 Apr 13;2:878–883. doi: 10.1016/j.redox.2014.04.003

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© 2014 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

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Fig. 2 — t-Bid induces EAA-L₄CL formation in isolated mitochondria and ApAP dose-dependently inhibits L₄CL oxidation and epoxyalcohol-aldehyde-CL formation.(A) Total ion chromatogram (TIC) of m/z 685.5 (doubly charged) in isolated mitochondria when treated with t-Bid. Arrow shows the putative EAA-CL peak. (B) MS spectrum of CID of m/z 685.5 at 6.33 min, EAA-CL. (C) MRM analysis of L₄CL oxidation products in isolated mitochondria after t-Bid treatment. SRM transitions are shown in Methods. (D) ApAP inhibits L₄CL oxidation and EAA-CL formation. L₄CL oxidation products are expressed as % of relative inhibition.