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. 2014 Jul 16;34(29):9506–9515. doi: 10.1523/JNEUROSCI.0693-14.2014

Figure 8.

Figure 8.

MGE cell transplantation rescued behavioral deficits of 17-month-old apoE4-KI mice at 70–80 DAT. A, MWM test showed a rescue of learning over 5 d of hidden platform trials in MGE cell-transplanted apoE4-KI mice, with no differences in visual trials. Points represent averages of daily trials. V, Visible platform day (two trials per session, two sessions per day). y-axis indicates the time to reach the target platform (escape latency, mean ± SEM). B, The probe trial of the MWM test showed a rescue of memory 120 h after the last learning trial in MGE cell-transplanted apoE4-KI mice. C, Swim speeds did not differ significantly among all groups. D, E, MGE cell transplantation ameliorated apoE4-induced behavioral deficits in the open field (D) and elevated plus maze (E) tests. Values are shown as the mean ± SEM. *p < 0.05 repeated-measures ANOVA (A), one-way ANOVA (C), and t test (B, D, and E). n = 9–13 mice per group.