Figure 9.
MGE cell transplantation rescued learning and memory deficits of 12-month-old apoE4-KI/hAPPFAD mice at 70–80 DAT. A, B, MWM test of learning (A) and memory (B) for transplanted and control apoE4-KI/hAPPFAD, wild-type, and apoE4-KI mice (n = 7–12 mice per group). C, D, Transplanted GFP+ cells survived and integrated in the dentate gyrus in the presence of plaques (C), with mature morphologies and processes extending through the plaques (D). E–G, DAB immunostaining of hippocampal Aβ (E) as well as quantification of plaque load (F) and Aβ levels (G) showed no significant effects of MGE cell transplantation on Aβ accumulation. n = 5–8 sections per brain, 5 mice per group. Values are shown as the mean ± SEM. **p < 0.01 repeated-measures ANOVA (A) and t test (B). Scale bars: C, 50 μm; D, 20 μm; E, 250 μm.