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. 2014 Jul 16;34(29):9607–9620. doi: 10.1523/JNEUROSCI.3788-13.2014

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Copyright © 2014 the authors 0270-6474/14/349607-14$15.00/0

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Figure 5. — AAV8-mediated astrocytic gene transfer of TFEB in astrocytes promotes lysosome biogenesis in APP/PS1 mice. A, Representative confocal images demonstrating expression of FLAG (green) and LAMP1 (red) in hippocampal tissues transduced with AAV8-GFAP-FLAG-TFEB (bottom) and AAV8-GFAP-eGFP (top) viral particles. Arrow indicates individual double-labeled cell shown under high magnification (insert, right upper corner). B, C, Immunoblots (B) with quantification (C) of lysosomal proteins in extracts from hippocampi transduced with AAV8-GFAP-FLAG-TFEB or AAV8-GFAP-eGFP. N = 3/group. D, Cathepsin B and D activity in extracts from hippocampi transduced with AAV8-GFAP-FLAG-TFEB or AAV8-GFAP-eGFP. N = 4/group; **p < 0.01.