Table 1.
Demographic and clinical data of the subjects
| HC | NfvPPA | SvPPA | LvPPA | |
|---|---|---|---|---|
| Age | 65.3 (3.9) | 67.3 (5.7) | 61.4 (5.6) | 63.6 (7.1) |
| Sex (F/M) | 13/8 | 6/3 | 5/3 | 4/4 |
| Education | 17.3 (2.2) | 15.1 (2.8) | 16.0 (1.5) | 16.1 (3.2) |
| Disease duration | NA | 4.2 (1.8) | 5.4 (3.2) | 5.1 (4.4) |
| MMSE (30) | 29.5 (0.7) | 25.1 (3.8)* | 24.4 (5.1)* | 23.8 (6.4)* |
| CDR | NA | 0.5 (0.4) | 0.8 (0.5) | 0.6 (0.2) |
| Speech and language evaluation | ||||
| WAB-Spontaneous Speech Fluency (10) | 0.0 (0.0) | 6.1 (1.8)*,b | 8.6 (0.9) | 8.1 (1.5) |
| WAB Rep Tot (100) | NA | 78.5 (10.2) | 84.1 (17.9) | 71.8 (17.1) |
| Boston Naming Test (15) | 14.6 (0.5) | 12.2 (2.0) | 6.2 (5.8)*a,c | 9.6 (5.0)* |
| MSE Apraxia of Speech Rating (0–7) | 0.0 (0.0) | 2.9 (1.3)*b,c | 0.0 (0.0) | 0.5 (1.1) |
| MSE Dysarthria Rating (0–7) | 0.0 (0.0) | 2.1 (2.1)*b | 0.0 (0.0) | 0.38 (1.1) |
| Speech Production Score (1) | 0.0 (0.0) | 0.63 (0.1)b,c | 0.92 (0.1) | 0.87 (0.1) |
| WAB Sequential Commands (80) | NA | 71.3 (8.5) | 65.3 (18.3) | 68.3 (11.8) |
| Pyramids and Palm Trees–Picture Version (52) | NA | 49.6 (1.4) | 41.3 (7.2)a,c | 50.4 (1.2) |
| Peabody Picture Vocabulary Test–Revised (16) | NA | 14.3 (1.3) | 6.5 (5)a,c | 13.3 (2.5) |
| Other cognitive domains | ||||
| Benson Figure Copy (17) | 15.0 (1.4) | 14.9 (1.8) | 15.6 (0.9) | 14.9 (1.1) |
| Benson Figure Delay Recall (17) | 11.5 (2.8) | 9.3 (3.5) | 7.0 (5.2)* | 7.3 (2.9) |
| Digit Span Backwards | 6.1 (1.4) | 3.1 (1.3)*b | 5.1 (1.1) | 3.3 (1.0)*b |
Values are reported as mean (SD).
*Significant differences compared with controls at p < 0.05.
an Significant differences from nonfluent variants at p < 0.05.
bn Significant differences from semantic variants at p < 0.05.
cn Significant differences from logopenic variants at p < 0.05.