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. 2014 Jul 16;34(29):9754–9767. doi: 10.1523/JNEUROSCI.3464-13.2014

Table 2.

Group differences in the frontal speech production tracts for all DTI metrics

Frontal tracts DTI metrics
HC NfvPPA p SvPPA p LvPPA p
BA44-SMAc
    Left
        FA 0.374 (0.019) 0.324 (0.028)*,b,c 0.000 0.368 (0.036) 0.95 0.371 (0.024) 0.99
        MD 0.600 (0.021) 0.677 (0.037)*,b,c 0.000 0.631 (0.039) 0.08 0.630 (0.024) 0.07
        AD 0.861 (0.024) 0.924 (0.040)* 0.000 0.900 (0.045) 0.08 0.893 (0.022) 0.07
        RD 0.472 (0.024) 0.552 (0.038)*,b,c 0.000 0.479 (0.043) 0.20 0.496 (0.030) 0.24
    Right
        FA 0.380 (0.025) 0.341 (0.031) 0.005 0.369 (0.03) 0.75 0.383 (0.023) 0.99
        MD 0.587 (0.020) 0.637 (0.042)* 0.000 0.617 (0.026) 0.07 0.598 (0.030) 0.79
        AD 0.844 (0.021) 0.877 (0.045) 0.38 0.878 (0.025) 0.06 0.860 (0.036) 0.56
        RD 0.458 (0.024) 0.516 (0.043)*,c 0.000 0.487 (0.034) 0.12 0.466 (0.032) 0.93
BA6vPMC-SMAc
    Left
        FA 0.384 (0.022) 0.331 (0.035)*,b,c 0.000 0.382 (0.032) 0.99 0.378 (0.029) 0.95
        MD 0.602 (0.018) 0.668 (0.051)*,b,c 0.000 0.616 (0.032) 0.67 0.614 (0.027) 0.77
        AD 0.850 (0.020) 0.915 (0.046)* 0.000 0.891 (0.043) 0.02 0.878 (0.028) 0.16
        RD 0.458 (0.024) 0.542 (0.054)*,b,c 0.000 0.477 (0.031) 0.55 0.482 (0.031) 0.34
    Right
        FA 0.393 (0.028) 0.359 (0.027) 0.01 0.386 (0.031) 0.92 0.397 (0.020) 0.98
        MD 0.579 (0.022) 0.639 (0.040)* 0.000 0.609 (0.030) 0.06 0.590 (0.027) 0.77
        AD 0.839 (0.025) 0.900 (0.049)* 0.000 0.884 (0.029) 0.01 0.856 (0.032) 0.59
        RD 0.446 (0.026) 0.509 (0.041)* 0.000 0.473 (0.033) 0.16 0.453 (0.028) 0.95
BA44-Caudate
    Left
        FA 0.324 (0.019) 0.292 (0.030) 0.01 0.305 (0.027) 0.25 0.303 (0.028) 0.20
        MD 0.628 (0.018) 0.710 (0.036)* 0.000 0.672 (0.057) 0.01 0.653 (0.035) 0.26
        AD 0.855 (0.021) 0.937 (0.040)* 0.000 0.901 (0.059) 0.02 0.880 (0.033) 0.34
        RD 0.512 (0.021) 0.591 (0.041)* 0.000 0.559 (0.059) 0.01 0.540 (0.035) 0.24
    Right
        FA 0.335 (0.023) 0.310 (0.023) 0.04 0.319 (0.027) 0.37 0.342 (0.017) 0.87
        MD 0.608 (0.020) 0.657 (0.037)* 0.000 0.631 (0.029) 0.16 0.620 (0.024) 0.67
        AD 0.834 (0.019) 0.888 (0.047)* 0.000 0.862 (0.040) 0.13 0.855 (0.028) 0.34
        RD 0.493 (0.022) 0.540 (0.035)* 0.000 0.515 (0.032) 0.21 0.499 (0.024) 0.95
BA44-Putamen
    Left
        FA 0.306 (0.019) 0.273 (0.016)* 0.001 0.286 (0.029) 0.10 0.292 (0.022) 0.37
        MD 0.633 (0.019) 0.701 (0.033)*,c 0.000 0.668 (0.040) 0.03 0.662 (0.036) 0.09
        AD 0.860 (0.023) 0.918 (0.034)*,b 0.000 0.877 (0.028) 0.47 0.886 (0.039) 0.14
        RD 0.523 (0.019) 0.593 (0.032)*,c 0.000 0.560 (0.043) 0.03 0.552 (0.035) 0.08
    Right
        FA 0.291 (0.018) 0.273 (0.016) 0.33 0.286 (0.029) 0.44 0.292 (0.022) 0.90
        MD 0.623 (0.021) 0.652 (0.031) 0.02 0.637 (0.026) 0.48 0.636 (0.023) 0.58
        AD 0.834 (0.024) 0.857 (0.032) 0.14 0.835 (0.025) 0.99 0.850 (0.026) 0.45
        RD 0.517 (0.020) 0.549 (0.030) 0.01 0.536 (0.031) 0.25 0.522 (0.027) 0.95
BA6vPMC-Caudate
    Left
        FA 0.363 (0.027) 0.333 (0.016) 0.01 0.369 (0.017) 0.90 0.375 (0.023) 0.61
        MD 0.591 (0.019) 0.674 (0.043)* 0.000 0.607 (0.033) 0.58 0.612 (0.028) 0.31
        AD 0.828 (0.021) 0.928 (0.061)* 0.000 0.862 (0.058) 0.17 0.878 (0.032) 0.02
        RD 0.473 (0.023) 0.543 (0.037)* 0.000 0.478 (0.024) 0.96 0.488 (0.026) 0.51
    Right
        FA 0.344 (0.019) 0.332 (0.018) 0.45 0.342 (0.027) 0.99 0.349 (0.022) 0.96
        MD 0.599 (0.018) 0.654 (0.041)* 0.000 0.620 (0.029) 0.22 0.608 (0.026) 0.83
        AD 0.822 (0.017) 0.899 (0.058)* 0.000 0.856 (0.049) 0.11 0.846 (0.029) 0.40
        RD 0.481 (0.021) 0.533 (0.036)* 0.000 0.499 (0.030) 0.37 0.488 (0.026) 0.92
BA6vPMC-Putamen
    Left
        FA 0.299 (0.027) 0.265 (0.025) 0.005 0.300 (0.020) 1.00 0.297 (0.019) 0.99
        MD 0.629 (0.022) 0.687 (0.036)* 0.000 0.632 (0.033) 0.99 0.648 (0.036) 0.44
        AD 0.849 (0.029) 0.897 (0.029) 0.002 0.851 (0.029) 0.99 0.871 (0.040) 0.33
        RD 0.519 (0.024) 0.581 (0.041)* 0.000 0.525 (0.032) 0.95 0.536 (0.03) 0.54
    Right
        FA 0.321 (0.016) 0.303 (0.026) 0.20 0.315 (0.027) 0.92 0.326 (0.028) 0.94
        MD 0.619 (0.023) 0.650 (0.030) 0.03 0.628 (0.025) 0.86 0.623 (0.035) 0.99
        AD 0.844 (0.029) 0.870 (0.030) 0.13 0.850 (0.031) 0.95 0.857 (0.029) 0.68
        RD 0.500 (0.017) 0.533 (0.030) 0.01 0.516 (0.028) 0.42 0.507 (0.034) 0.92
SMAc-Caudate
    Left
        FA 0.364 (0.028) 0.306 (0.032)*,b 0.000 0.346 (0.037) 0.48 0.338 (0.027) 0.17
        MD 0.610 (0.020) 0.698 (0.050)*,b,c 0.000 0.646 (0.046) 0.06 0.641 (0.027) 0.10
        AD 0.865 (0.021) 0.940 (0.056)*,c 0.000 0.904 (0.045) 0.06 0.893 (0.023) 0.23
        RD 0.481 (0.027) 0.576 (0.050)*,b,c 0.000 0.517 (0.051) 0.09 0.515 (0.032) 0.12
    Right
        FA 0.352 (0.025) 0.304 (0.020)*,c 0.000 0.327(0.029) 0.07 0.345 (0.023) 0.90
        MD 0.613 (0.020) 0.678 (0.043)*,c 0.000 0.641 (0.029) 0.09 0.625 (0.025) 0.71
        AD 0.862 (0.019) 0.916 (0.048)* 0.000 0.889 (0.026) 0.12 0.880 (0.032) 0.45
        RD 0.486 (0.026) 0.559 (0.042)*,b,c 0.000 0.518 (0.035) 0.08 0.500 (0.028) 0.71
SMAc-Putamen
    Left
        FA 0.337 (0.025) 0.308 (0.036) 0.01 0.350 (0.038) 0.74 0.334 (0.033) 0.99
        MD 0.608 (0.021) 0.678 (0.040)*,b,c 0.000 0.631 (0.041) 0.27 0.637 (0.030) 0.10
        AD 0.847 (0.021) 0.925 (0.034)*,c 0.000 0.889 (0.041) 0.003 0.887 (0.022) 0.01
        RD 0.486 (0.026) 0.555 (0.046)*,b 0.000 0.501 (0.046) 0.76 0.512 (0.036) 0.31
    Right
        FA 0.356 (0.029) 0.325 (0.027) 0.04 0.354 (0.033) 0.99 0.359 (0.023) 0.99
        MD 0.591 (0.019) 0.647 (0.037)* 0.000 0.614 (0.031) 0.19 0.604 (0.028) 0.67
        AD 0.836 (0.021) 0.889 (0.037)* 0.000 0.864 (0.030) 0.08 0.861 (0.032) 0.14
        RD 0.464 (0.025) 0.524 (0.042)* 0.000 0.488 (0.036) 0.27 0.475 (0.031) 0.84
SMAc-Insula
    Left
        FA 0.370 (0.030) 0.342 (0.038) 0.18 0.400 (0.039) 0.10 0.377 (0.032) 0.98
        MD 0.600 (0.022) 0.674 (0.040)* 0.000 0.624 (0.039) 0.28 0.630 (0.026) 0.05
        AD 0.861 (0.027) 0.942 (0.045)* 0.000 0.918 (0.050) 0.004 0.902 (0.023) 0.03
        RD 0.470 (0.028) 0.543 (0.042)* 0.000 0.479 (0.041) 0.98 0.491 (0.035) 0.36
    Right
        FA 0.367 (0.039) 0.340 (0.035) 0.14 0.381 (0.035) 0.62 0.375 (0.028) 0.90
        MD 0.587 (0.019) 0.642 (0.044)* 0.000 0.614 (0.035) 0.11 0.600 (0.033) 0.42
        AD 0.843 (0.030) 0.900 (0.047) 0.003 0.887 (0.031) 0.01 0.864 (0.041) 0.12
        RD 0.458 (0.023) 0.514 (0.045)* 0.000 0.476 (0.036) 0.61 0.464 (0.033) 0.90
BA44-Insula
    Left
        FA 0.297 (0.021) 0.261 (0.021) 0.003 0.280 (0.027) 0.35 0.292 (0.021) 0.94
        MD 0.639 (0.020) 0.702 (0.033)* 0.000 0.675 (0.040) 0.05 0.660 (0.035) 0.25
        AD 0.867 (0.024) 0.912 (0.032) 0.004 0.890 (0.034) 0.40 0.885 (0.039) 0.34
        RD 0.531 (0.020) 0.600 (0.034)* 0.000 0.569 (0.041) 0.03 0.551 (0.033) 0.25
    Right
        FA 0.295 (0.021) 0.275 (0.025) 0.21 0.284 (0.019) 0.40 0.301(0.019) 0.99
        MD 0.626 (0.020) 0.658 (0.035) 0.02 0.640 (0.019) 0.38 0.638 (0.022) 0.43
        AD 0.841 (0.021) 0.860 (0.032) 0.24 0.848 (0.022) 0.94 0.859 (0.020) 0.30
        RD 0.521 (0.023) 0.559(0.038) 0.02 0.536 (0.022) 0.42 0.525 (0.026) 0.86
BA6vPMC-Insula
    Left
        FA 0.299 (0.023) 0.266 (0.029) 0.005 0.307 (0.015) 0.77 0.298 (0.016) 0.99
        MD 0.640 (0.018) 0.690 (0.035)* 0.000 0.648 (0.031) 0.82 0.662 (0.022) 0.13
        AD 0.862 (0.024) 0.900 (0.035) 0.03 0.866 (0.030) 0.93 0.887 (0.034) 0.05
        RD 0.529 (0.022) 0.587 (0.038)* 0.000 0.537 (0.027) 0.92 0.550 (0.022) 0.25
    Right
        FA 0.317 (0.018) 0.288 (0.025) 0.02 0.312 (0.024) 0.90 0.317 (0.029) 0.98
        MD 0.637 (0.020) 0.662 (0.031) 0.16 0.642 (0.021) 0.91 0.643 (0.035) 0.77
        AD 0.863 (0.026) 0.873 (0.029) 0.95 0.865 (0.024) 0.51 0.874 (0.030) 0.97
        RD 0.522 (0.017) 0.556 (0.034) 0.03 0.529 (0.025) 0.88 0.527 (0.036) 0.83

MD, AD, and RD values are reported as mean (SD) in mm2/s × 10−3.

*Significant differences between PPA variants and healthy controls at p < 0.002 (Bonferroni adjusted).

an Significant differences from nonfluent variants at p < 0.05.

bn Significant differences from semantic variants at p < 0.05.

cn Significant differences from logopenic variants at p < 0.05.