Table 2.
Frontal tracts | DTI metrics |
||||||
---|---|---|---|---|---|---|---|
HC | NfvPPA | p | SvPPA | p | LvPPA | p | |
BA44-SMAc | |||||||
Left | |||||||
FA | 0.374 (0.019) | 0.324 (0.028)*,b,c | 0.000 | 0.368 (0.036) | 0.95 | 0.371 (0.024) | 0.99 |
MD | 0.600 (0.021) | 0.677 (0.037)*,b,c | 0.000 | 0.631 (0.039) | 0.08 | 0.630 (0.024) | 0.07 |
AD | 0.861 (0.024) | 0.924 (0.040)* | 0.000 | 0.900 (0.045) | 0.08 | 0.893 (0.022) | 0.07 |
RD | 0.472 (0.024) | 0.552 (0.038)*,b,c | 0.000 | 0.479 (0.043) | 0.20 | 0.496 (0.030) | 0.24 |
Right | |||||||
FA | 0.380 (0.025) | 0.341 (0.031) | 0.005 | 0.369 (0.03) | 0.75 | 0.383 (0.023) | 0.99 |
MD | 0.587 (0.020) | 0.637 (0.042)* | 0.000 | 0.617 (0.026) | 0.07 | 0.598 (0.030) | 0.79 |
AD | 0.844 (0.021) | 0.877 (0.045) | 0.38 | 0.878 (0.025) | 0.06 | 0.860 (0.036) | 0.56 |
RD | 0.458 (0.024) | 0.516 (0.043)*,c | 0.000 | 0.487 (0.034) | 0.12 | 0.466 (0.032) | 0.93 |
BA6vPMC-SMAc | |||||||
Left | |||||||
FA | 0.384 (0.022) | 0.331 (0.035)*,b,c | 0.000 | 0.382 (0.032) | 0.99 | 0.378 (0.029) | 0.95 |
MD | 0.602 (0.018) | 0.668 (0.051)*,b,c | 0.000 | 0.616 (0.032) | 0.67 | 0.614 (0.027) | 0.77 |
AD | 0.850 (0.020) | 0.915 (0.046)* | 0.000 | 0.891 (0.043) | 0.02 | 0.878 (0.028) | 0.16 |
RD | 0.458 (0.024) | 0.542 (0.054)*,b,c | 0.000 | 0.477 (0.031) | 0.55 | 0.482 (0.031) | 0.34 |
Right | |||||||
FA | 0.393 (0.028) | 0.359 (0.027) | 0.01 | 0.386 (0.031) | 0.92 | 0.397 (0.020) | 0.98 |
MD | 0.579 (0.022) | 0.639 (0.040)* | 0.000 | 0.609 (0.030) | 0.06 | 0.590 (0.027) | 0.77 |
AD | 0.839 (0.025) | 0.900 (0.049)* | 0.000 | 0.884 (0.029) | 0.01 | 0.856 (0.032) | 0.59 |
RD | 0.446 (0.026) | 0.509 (0.041)* | 0.000 | 0.473 (0.033) | 0.16 | 0.453 (0.028) | 0.95 |
BA44-Caudate | |||||||
Left | |||||||
FA | 0.324 (0.019) | 0.292 (0.030) | 0.01 | 0.305 (0.027) | 0.25 | 0.303 (0.028) | 0.20 |
MD | 0.628 (0.018) | 0.710 (0.036)* | 0.000 | 0.672 (0.057) | 0.01 | 0.653 (0.035) | 0.26 |
AD | 0.855 (0.021) | 0.937 (0.040)* | 0.000 | 0.901 (0.059) | 0.02 | 0.880 (0.033) | 0.34 |
RD | 0.512 (0.021) | 0.591 (0.041)* | 0.000 | 0.559 (0.059) | 0.01 | 0.540 (0.035) | 0.24 |
Right | |||||||
FA | 0.335 (0.023) | 0.310 (0.023) | 0.04 | 0.319 (0.027) | 0.37 | 0.342 (0.017) | 0.87 |
MD | 0.608 (0.020) | 0.657 (0.037)* | 0.000 | 0.631 (0.029) | 0.16 | 0.620 (0.024) | 0.67 |
AD | 0.834 (0.019) | 0.888 (0.047)* | 0.000 | 0.862 (0.040) | 0.13 | 0.855 (0.028) | 0.34 |
RD | 0.493 (0.022) | 0.540 (0.035)* | 0.000 | 0.515 (0.032) | 0.21 | 0.499 (0.024) | 0.95 |
BA44-Putamen | |||||||
Left | |||||||
FA | 0.306 (0.019) | 0.273 (0.016)* | 0.001 | 0.286 (0.029) | 0.10 | 0.292 (0.022) | 0.37 |
MD | 0.633 (0.019) | 0.701 (0.033)*,c | 0.000 | 0.668 (0.040) | 0.03 | 0.662 (0.036) | 0.09 |
AD | 0.860 (0.023) | 0.918 (0.034)*,b | 0.000 | 0.877 (0.028) | 0.47 | 0.886 (0.039) | 0.14 |
RD | 0.523 (0.019) | 0.593 (0.032)*,c | 0.000 | 0.560 (0.043) | 0.03 | 0.552 (0.035) | 0.08 |
Right | |||||||
FA | 0.291 (0.018) | 0.273 (0.016) | 0.33 | 0.286 (0.029) | 0.44 | 0.292 (0.022) | 0.90 |
MD | 0.623 (0.021) | 0.652 (0.031) | 0.02 | 0.637 (0.026) | 0.48 | 0.636 (0.023) | 0.58 |
AD | 0.834 (0.024) | 0.857 (0.032) | 0.14 | 0.835 (0.025) | 0.99 | 0.850 (0.026) | 0.45 |
RD | 0.517 (0.020) | 0.549 (0.030) | 0.01 | 0.536 (0.031) | 0.25 | 0.522 (0.027) | 0.95 |
BA6vPMC-Caudate | |||||||
Left | |||||||
FA | 0.363 (0.027) | 0.333 (0.016) | 0.01 | 0.369 (0.017) | 0.90 | 0.375 (0.023) | 0.61 |
MD | 0.591 (0.019) | 0.674 (0.043)* | 0.000 | 0.607 (0.033) | 0.58 | 0.612 (0.028) | 0.31 |
AD | 0.828 (0.021) | 0.928 (0.061)* | 0.000 | 0.862 (0.058) | 0.17 | 0.878 (0.032) | 0.02 |
RD | 0.473 (0.023) | 0.543 (0.037)* | 0.000 | 0.478 (0.024) | 0.96 | 0.488 (0.026) | 0.51 |
Right | |||||||
FA | 0.344 (0.019) | 0.332 (0.018) | 0.45 | 0.342 (0.027) | 0.99 | 0.349 (0.022) | 0.96 |
MD | 0.599 (0.018) | 0.654 (0.041)* | 0.000 | 0.620 (0.029) | 0.22 | 0.608 (0.026) | 0.83 |
AD | 0.822 (0.017) | 0.899 (0.058)* | 0.000 | 0.856 (0.049) | 0.11 | 0.846 (0.029) | 0.40 |
RD | 0.481 (0.021) | 0.533 (0.036)* | 0.000 | 0.499 (0.030) | 0.37 | 0.488 (0.026) | 0.92 |
BA6vPMC-Putamen | |||||||
Left | |||||||
FA | 0.299 (0.027) | 0.265 (0.025) | 0.005 | 0.300 (0.020) | 1.00 | 0.297 (0.019) | 0.99 |
MD | 0.629 (0.022) | 0.687 (0.036)* | 0.000 | 0.632 (0.033) | 0.99 | 0.648 (0.036) | 0.44 |
AD | 0.849 (0.029) | 0.897 (0.029) | 0.002 | 0.851 (0.029) | 0.99 | 0.871 (0.040) | 0.33 |
RD | 0.519 (0.024) | 0.581 (0.041)* | 0.000 | 0.525 (0.032) | 0.95 | 0.536 (0.03) | 0.54 |
Right | |||||||
FA | 0.321 (0.016) | 0.303 (0.026) | 0.20 | 0.315 (0.027) | 0.92 | 0.326 (0.028) | 0.94 |
MD | 0.619 (0.023) | 0.650 (0.030) | 0.03 | 0.628 (0.025) | 0.86 | 0.623 (0.035) | 0.99 |
AD | 0.844 (0.029) | 0.870 (0.030) | 0.13 | 0.850 (0.031) | 0.95 | 0.857 (0.029) | 0.68 |
RD | 0.500 (0.017) | 0.533 (0.030) | 0.01 | 0.516 (0.028) | 0.42 | 0.507 (0.034) | 0.92 |
SMAc-Caudate | |||||||
Left | |||||||
FA | 0.364 (0.028) | 0.306 (0.032)*,b | 0.000 | 0.346 (0.037) | 0.48 | 0.338 (0.027) | 0.17 |
MD | 0.610 (0.020) | 0.698 (0.050)*,b,c | 0.000 | 0.646 (0.046) | 0.06 | 0.641 (0.027) | 0.10 |
AD | 0.865 (0.021) | 0.940 (0.056)*,c | 0.000 | 0.904 (0.045) | 0.06 | 0.893 (0.023) | 0.23 |
RD | 0.481 (0.027) | 0.576 (0.050)*,b,c | 0.000 | 0.517 (0.051) | 0.09 | 0.515 (0.032) | 0.12 |
Right | |||||||
FA | 0.352 (0.025) | 0.304 (0.020)*,c | 0.000 | 0.327(0.029) | 0.07 | 0.345 (0.023) | 0.90 |
MD | 0.613 (0.020) | 0.678 (0.043)*,c | 0.000 | 0.641 (0.029) | 0.09 | 0.625 (0.025) | 0.71 |
AD | 0.862 (0.019) | 0.916 (0.048)* | 0.000 | 0.889 (0.026) | 0.12 | 0.880 (0.032) | 0.45 |
RD | 0.486 (0.026) | 0.559 (0.042)*,b,c | 0.000 | 0.518 (0.035) | 0.08 | 0.500 (0.028) | 0.71 |
SMAc-Putamen | |||||||
Left | |||||||
FA | 0.337 (0.025) | 0.308 (0.036) | 0.01 | 0.350 (0.038) | 0.74 | 0.334 (0.033) | 0.99 |
MD | 0.608 (0.021) | 0.678 (0.040)*,b,c | 0.000 | 0.631 (0.041) | 0.27 | 0.637 (0.030) | 0.10 |
AD | 0.847 (0.021) | 0.925 (0.034)*,c | 0.000 | 0.889 (0.041) | 0.003 | 0.887 (0.022) | 0.01 |
RD | 0.486 (0.026) | 0.555 (0.046)*,b | 0.000 | 0.501 (0.046) | 0.76 | 0.512 (0.036) | 0.31 |
Right | |||||||
FA | 0.356 (0.029) | 0.325 (0.027) | 0.04 | 0.354 (0.033) | 0.99 | 0.359 (0.023) | 0.99 |
MD | 0.591 (0.019) | 0.647 (0.037)* | 0.000 | 0.614 (0.031) | 0.19 | 0.604 (0.028) | 0.67 |
AD | 0.836 (0.021) | 0.889 (0.037)* | 0.000 | 0.864 (0.030) | 0.08 | 0.861 (0.032) | 0.14 |
RD | 0.464 (0.025) | 0.524 (0.042)* | 0.000 | 0.488 (0.036) | 0.27 | 0.475 (0.031) | 0.84 |
SMAc-Insula | |||||||
Left | |||||||
FA | 0.370 (0.030) | 0.342 (0.038) | 0.18 | 0.400 (0.039) | 0.10 | 0.377 (0.032) | 0.98 |
MD | 0.600 (0.022) | 0.674 (0.040)* | 0.000 | 0.624 (0.039) | 0.28 | 0.630 (0.026) | 0.05 |
AD | 0.861 (0.027) | 0.942 (0.045)* | 0.000 | 0.918 (0.050) | 0.004 | 0.902 (0.023) | 0.03 |
RD | 0.470 (0.028) | 0.543 (0.042)* | 0.000 | 0.479 (0.041) | 0.98 | 0.491 (0.035) | 0.36 |
Right | |||||||
FA | 0.367 (0.039) | 0.340 (0.035) | 0.14 | 0.381 (0.035) | 0.62 | 0.375 (0.028) | 0.90 |
MD | 0.587 (0.019) | 0.642 (0.044)* | 0.000 | 0.614 (0.035) | 0.11 | 0.600 (0.033) | 0.42 |
AD | 0.843 (0.030) | 0.900 (0.047) | 0.003 | 0.887 (0.031) | 0.01 | 0.864 (0.041) | 0.12 |
RD | 0.458 (0.023) | 0.514 (0.045)* | 0.000 | 0.476 (0.036) | 0.61 | 0.464 (0.033) | 0.90 |
BA44-Insula | |||||||
Left | |||||||
FA | 0.297 (0.021) | 0.261 (0.021) | 0.003 | 0.280 (0.027) | 0.35 | 0.292 (0.021) | 0.94 |
MD | 0.639 (0.020) | 0.702 (0.033)* | 0.000 | 0.675 (0.040) | 0.05 | 0.660 (0.035) | 0.25 |
AD | 0.867 (0.024) | 0.912 (0.032) | 0.004 | 0.890 (0.034) | 0.40 | 0.885 (0.039) | 0.34 |
RD | 0.531 (0.020) | 0.600 (0.034)* | 0.000 | 0.569 (0.041) | 0.03 | 0.551 (0.033) | 0.25 |
Right | |||||||
FA | 0.295 (0.021) | 0.275 (0.025) | 0.21 | 0.284 (0.019) | 0.40 | 0.301(0.019) | 0.99 |
MD | 0.626 (0.020) | 0.658 (0.035) | 0.02 | 0.640 (0.019) | 0.38 | 0.638 (0.022) | 0.43 |
AD | 0.841 (0.021) | 0.860 (0.032) | 0.24 | 0.848 (0.022) | 0.94 | 0.859 (0.020) | 0.30 |
RD | 0.521 (0.023) | 0.559(0.038) | 0.02 | 0.536 (0.022) | 0.42 | 0.525 (0.026) | 0.86 |
BA6vPMC-Insula | |||||||
Left | |||||||
FA | 0.299 (0.023) | 0.266 (0.029) | 0.005 | 0.307 (0.015) | 0.77 | 0.298 (0.016) | 0.99 |
MD | 0.640 (0.018) | 0.690 (0.035)* | 0.000 | 0.648 (0.031) | 0.82 | 0.662 (0.022) | 0.13 |
AD | 0.862 (0.024) | 0.900 (0.035) | 0.03 | 0.866 (0.030) | 0.93 | 0.887 (0.034) | 0.05 |
RD | 0.529 (0.022) | 0.587 (0.038)* | 0.000 | 0.537 (0.027) | 0.92 | 0.550 (0.022) | 0.25 |
Right | |||||||
FA | 0.317 (0.018) | 0.288 (0.025) | 0.02 | 0.312 (0.024) | 0.90 | 0.317 (0.029) | 0.98 |
MD | 0.637 (0.020) | 0.662 (0.031) | 0.16 | 0.642 (0.021) | 0.91 | 0.643 (0.035) | 0.77 |
AD | 0.863 (0.026) | 0.873 (0.029) | 0.95 | 0.865 (0.024) | 0.51 | 0.874 (0.030) | 0.97 |
RD | 0.522 (0.017) | 0.556 (0.034) | 0.03 | 0.529 (0.025) | 0.88 | 0.527 (0.036) | 0.83 |
MD, AD, and RD values are reported as mean (SD) in mm2/s × 10−3.
*Significant differences between PPA variants and healthy controls at p < 0.002 (Bonferroni adjusted).
an Significant differences from nonfluent variants at p < 0.05.
bn Significant differences from semantic variants at p < 0.05.
cn Significant differences from logopenic variants at p < 0.05.