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. 2014 Jul 16;5:264. doi: 10.3389/fphys.2014.00264

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Copyright © 2014 Xie, Kauffman and Akar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective effect of CsA is abolished by PKC inhibition. (A) For reference, ΔΨ_m response presented in Figure 1 indicating protection by CsA against OS-induced ΔΨ_m depolarization. (B) Average ΔΨ_m response to CsA treatment in the presence of the specific PKC inhibitor CHE. (C) Average ΔΨ_m response in control and CHE treated hearts. CHE alone (i.e., without CsA) did not alter the response. CHE, Chelerythrine; PKC, Protein kinase C.