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. 2014 Jul 16;5:264. doi: 10.3389/fphys.2014.00264

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Copyright © 2014 Xie, Kauffman and Akar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective effect of CsA is modulated by mK_ATP. (A) For reference, ΔΨ_m response presented in Figure 1 indicating protection by CsA against OS-induced ΔΨ_m depolarization. (B) Treatment with the mK_ATP antagonist abrogates the protective effect of CsA on mitochondrial dysfunction. (C) mK_ATP activation by DZX protects against OS-induced ΔΨ_m depolarization. (D) BDM abolishes the protective effect of DZX on mitochondrial dysfunction. DZX, Diazoxide.