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. 2014 Jul 16;5:264. doi: 10.3389/fphys.2014.00264

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Copyright © 2014 Xie, Kauffman and Akar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) ΔΨ_m at 15 min of OS normalized to baseline value in control and CsA treated hearts. (B,C) Representative action potentials recorded during early challenge with acute OS in control and CsA treated hearts. AP shortening is more pronounced in CsA compared to control hearts, indicating heightened sensitivity to OS. (D) OS-induced % change in APD relative to baseline (pre-H₂O₂ value) in control and CsA treated hearts. (E) Representative APD contour maps showing global shortening of APD in response to OS in CsA treated hearts compared to controls.