Table 3.
Summary of the local control rates from the previously reported series of intracranial and spinal hemangioblastoma treated with radiosurgery
| author | No of Pts | Location | RT technique | Sporadic/VHL | Median F/U (range) (months) | Median dose (range) (Gy) | Median volume (range) (cm3) | 2 year | 5 year | 10 year | Complication |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Niemela, 1996 [5] | 10 | brain | GK | 6/4 | 26 (4–68) | 6–25 (20–25) 7–10 (5–19) | N/A | 100 | 1 Cerebellar edema 1 SIADH | ||
| Patrice, 1996 [6] | 22 | brain | linac/GK | 13/9 | 24.5 (6–77) | 15.5 (12–20) | 0.97 (0.05–12) | 86 | none | ||
| Jawahar, 2000 [7] | 27 | brain | GK | 13/14 | 48 (6–108) | 16 (11.7–20) | 3.2 (0.36–27) | 89.5 | 75.2 | none | |
| Park, 2005 [8] | 9 | brain | GK | 4/5 | 51 (8.6–141) | 16.6 (12.8–29.75) | N/A | 96 | 1-radiation-induced brain injury | ||
| Tago, 2005 [9] | 13 | brain | GK | 6/7 | 36 (3–159) | 20 (18–20) | 0.23 (0.004–4.84) | 96.2 | 96.2 | none | |
| Wang, 2005 [10] | 35 | brain | GK | 14/21 | 66 (24–114) | 17.2 (12–24) | N/A | 94 | 71 | none | |
| Matsunaga, 2007 [11] | 22 | brain | GK | 12/10 | 63 (9–146) | 14 (8–30) | 1.69 (0.0097–16.4) | 88 | 78 | none | |
| Kano, 2008 [12] | 32 | brain | GK | 19/13 | 50.1 (6.0–165.4) | 16.0 (11–20) | 0.72 (0.08–16.6) | 91.9 | none | ||
| Moss, 2009 [13] | 31 | brain and spine | Linac/CK | 5/26 | 69(5–164) | 23.4 (12–40) | 1. (0.058–65.4) | 85 (at 3 years) | 82 | 5-radiation necrosis | |
| Karabagli, 2010 [14] | 13 | brain | GK | 6/7 | 50.2 (24–116) | 15.8 (12–25) | 0.022 (0.0005–11.37) | 100 | none | ||
| Sayer, 2011 [15] | 14 | brain | GK | 7/7 | 36 (6–144) | 18 (10–25) | 1.65 (0.08–9.02) | 74 | 50 | none | |
| Selch, 2012 [16] | 9 | spine | linac | 4/5 | 51(14–86) | 12 | 0.7 (0.08–14.4) | 95 (at 4 years) | none | ||
| Our study | 14 | brain | linac/CK | 5/9 | 24 (11–89) | 20(10–32) | 0.26 (0.026–20.4) | 88% | 73 (at 6 years) | none |
GK = GammaKnife, VHL = Von-Hippel-Lindau disease, CK = CyberKnife, SIADH = syndrome of inappropriate antidiuretic hormone secretion, N/A = data not available.