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. 2014 May 27;15(6):9372–9385. doi: 10.3390/ijms15069372

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Apoptosis of retinal cells at laser spots in mice treated with or without MSCs. Retinas of the injured control group (a–d) and MSC-treated group (e–h). Green indicates terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick-end labeling (TUNEL)+ cells. Blue indicates DAPI-stained nuclei. Scale bars: 50 μm. The average numbers of apoptotic cells were calculated and found to be significantly reduced in the MSC-treated group at all time points compared with those in the injured control group (i). *, p < 0.05. Scale bars: 50 µm. GCL, ganglion cell layer; INL, inner nuclear layer.