Table 1.
Summarization of facts about cholinesterases’ inhibitors.
| Group of Compounds | Compounds (Examples) | Mechanism of Inhibition | Inhibition of AChE and BChE | Penetration through Blood Brain Barrier | Importance as Drugs | References |
|---|---|---|---|---|---|---|
| Organophosphates | sarin, soman, tabun, malaoxon | irreversible | equal to AChE and BChE | Good | Low | [6,43,44,45,46,47,48,49,50] |
| Carbamates | pyridostigmine, physostigmine neostigmine, rivastigmine | pseudo-irreversible | equal to AChE and BChE | low (pyridostigmine, neostigmine), good (physostigmine, rivastigmine) | High | [29,53,54,55,56,57,58,59,60] |
| - | Tacrine | non-competitive | AChE > BChE | Good | former drug, discontinued now | [53,66,68,69] |
| - | Galantamine | competitive | AChE | Good | High | [73,74] |
| - | Donepezil | non-competitive | AChE | Good | High | [75,76] |
| - | huperzine A | non-competitive | AChE >> BChE | Good | will increase | [29,75,77,78,79] |