Table 5.
Distribution of HLA-DP alleles among the group of anti-F negative patients, anti-F positive patients and healthy controls.
| Alleles | Anti-F Positive n = 516 (%) | Anti-F Negative n = 186 (%) | Healthy Controls * n = 334 (%) | Cases † vs. Healthy Controls | Anti-F Positive vs. Anti-F Negative | ||
|---|---|---|---|---|---|---|---|
| OR (95% CI) | Padj ** | OR (95% CI) | Padj ** | ||||
| HLA-DPA1 alleles | |||||||
| DPA1*0103 | 410 (39.7) | 150 (40.3) | 218 (32.6) | 2.45 (2.0–3.0) | <0.001 | 0.98 (0.77–1.24) | NS |
| DPA1*0201 | 96 (9.3) | 56 (15.1) | 82 (12.3) | 1.23 (0.93–1.65) | NS | 0.58 (0.41–0.82) | 0.006 |
| DPA1*0202 | 526 (51.0) | 166 (44.6) | 368 (55.1) | 0.79 (0.66–0.95) | 0.042 | 1.29 (1.02–1.64) | NS |
| HLA-DPB1 alleles | |||||||
| DPB1*0201 | 218 (21.1) | 73 (19.6) | 91 (13.6) | 1.66 (1.28–2.14) | <0.001 | 1.10 (0.82–1.48) | NS |
| DPB1*0202 | 124 (20.7) | 29 (7.8) | 108 (16.2) | 0.63 (0.49–0.83) | 0.016 | 1.62 (1.06–2.47) | NS |
| DPB1*0301 | 28 (2.7) | 8 (2.2) | 8 (1.2) | 2.17 (1.00–4.70) | NS | 1.27 (0.57–2.81) | NS |
| DPB1*0401 | 64 (6.2) | 22 (5.9) | 52 (7.8) | 0.78 (0.54–1.11) | NS | 1.05 (0.64–1.73) | NS |
| DPB1*0402 | 160 (15.5) | 57 (15.3) | 124 (18.6) | 0.80 (0.63–1.02) | NS | 1.01 (0.73–1.41) | NS |
| DPB1*0501 | 314 (30.4) | 121 (32.5) | 210 (31.4) | 0.98 (0.80–1.19) | NS | 0.91 (0.70–1.17) | NS |
| DPB1*0601 | 2 (0.2) | 2 (0.5) | 6 (0.9) | 0.32 (0.09–1.12) | NS | 0.26 (0.04–1.88) | NS |
| DPB1*0901 | 12 (1.2) | 7 (1.9) | 10 (1.5) | 0.90 (0.42–1.95) | NS | 0.61 (0.24–1.57) | NS) |
| DPB1*1301 | 20 (1.9) | 4 (1.1) | 8 (1.2) | 1.44 (0.64–3.21) | NS | 1.82 (0.62–5.36) | NS |
| DPB1*1401 | 0 (0) | 8 (2.2) | 12 (1.8) | 0.31 (0.13–0.77) | NS | 4.86 (4.43–5.32) | <0.001 |
| DPB1*1701 | 16 (1.6) | 11(3.0) | 12 (1.8) | 1.07 (0.54–2.13) | NS | 0.52 (0.24–1.12) | NS |
| DPB1*1901 | 20 (1.9) | 7 (1.9) | 7 (1.0) | 1.85 (0.80–4.27) | NS | 1.03 (0.43–2.46) | NS |
| DPB1*1001 | 18 (1.7) | 10 (2.7) | 8 (1.2) | 1.68 (0.76–3.70) | NS | 0.64 (0.29–1.41) | NS |
| DPB1*1601 | 8 (0.8) | 5 (1.3) | 3 (0.4) | 2.07 (0.59–7.30) | NS | 0.42 (0.14–1.29) | NS |
| DPB1*2101 | 16 (1.6) | 3 (0.8) | 3 (0.4) | 3.04 (0.90–10.31) | NS | 1.94 (0.56–6.69) | NS |
| DPB1*3901 | 2 (0.2) | 0 (0) | 2 (0.3) | 0.48 (0.07–3.38) | NS | 1.36 (1.32–1.41) | NS |
* Healthy controls: 8 samples were excluded because of genotyping failure; † Cases including the group of anti-F positive and anti-F negative; ** The p value were adjusted (padj) for multiple alleles by applying the Bonferroni correction of multiplying the p value by the total number of alleles tested in each locus.