Table 1.

DNA adduct formation by 1 μM 3-NBA and AAI activated by human NQO1 and NATs (NAT1/2) and SULTs (SULT1A1/2).

Enzymatic System	Total Levels of DNA Adducts in RAL a (Mean ± SD/108 Nucleotides)
	3-NBA	AAI
NQO1 + NADPH	10 ± 2	15 ± 2
NQO1 + NADPH + dicoumarol	0.1 ± 0.01	0.4 ± 0.04
NQO1 + NADPH + SULT1A1 + PAPS b	16 ± 2	15 ± 2
NQO1 + NADPH + SULT1A2 + PAPS	36 ± 2	16 ± 2
NQO1 + NADPH + NAT1 + acetyl-CoA c	16 ± 2	15 ± 2
NQO1 + NADPH + NAT2 + acetyl-CoA	1720 ± 50	17 ± 2

^a, RAL, relative adduct labeling; Results are presented as means ± SD of triplicate in-vitro incubations. Experimental conditions are as described [52,69]; ^b, 0.4 mM PAPS; ^c, 2 mM acetyl-CoA