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. 2014 Jun 18;15(6):11013–11029. doi: 10.3390/ijms150611013

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© 2014 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

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Differential gene expression between MB-DP and MB-DN cells. (A) Heatmap of differential gene expression between MB-DP and MB-DN cells. Gene expression microarray analysis showing genes that were differentially expressed in MB-DP and MB-DN cells. In bioinformatics analysis of differential gene expression, the JAK-STAT cascade and related pathway were found to be the most significantly different between MB-DP and MB-DN cells; (B) The results of western blot show the upregulation of Cox2, Nestin, CD133, phosphorylated-STAT3 and STAT3-related protein, JAK2, BCL2, c-Myc in MB-DP cells but not in MB-DNs; and (C) The data of real-time quantitative PCR show that the Cox2, Nestin, CD133 and STAT3-related genes were highly expression in MB-DPs but not in MB-DNs.