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. Author manuscript; available in PMC: 2015 Aug 1.
Published in final edited form as: Dis Colon Rectum. 2014 Aug;57(8):941–957. doi: 10.1097/DCR.0000000000000160

Table 2.

Differentially Methylated CpG Loci in Clinically defined Low and High-risk anal cancers

Symbol Product Association with Disease CpG Numbera Median Beta value p-valuec
Low Risk High Risk Difb MW T-Test
ADAT3d Adenosine deaminase, tRNA-specific 3 Not reported as target of methylation or involved in cancer cg20243900 0.64 0.75 0.11 5.48E-04 2.01E-04
GSG1L Germ Cell Associated 1 (GSG1)-Like Possible susceptibility locus for colon cancer in AOM mouse models; Not reported as target of methylation. cg09528825 0.07 0.18 0.11 3.12E-02 8.15E-04
KIAA0319 KIAA0319 Dyslexia-associated gene, Not reported as target of methylation or involved in cancer cg18428180 0.24 0.09 −0.15 1.29E-03 4.87E-04
LOC-728392 LOC728392 Not reported as target of methylation or involved in cancer cg18671949 0.11 0.40 0.29 4.96E-05 9.84E-06
cg06462347 0.24 0.53 0.28 1.43E-04 5.17E-05
cg27230784 0.14 0.51 0.37 4.44E-05 4.58E-05
cg22298430 0.15 0.47 0.32 1.49E-04 7.13E-05
cg01433610 0.38 0.52 0.15 1.66E-03 8.04E-04
PARD3 Partitioning defective 3 homolog Lost in prostate cancer23, involved in cell motility; Associated with WNT/β-catenin pathway24; Not reported as a target of methylation. cg26795540 0.48 0.58 0.10 7.57E-04 1.60E-03
SALL3 SAL-Like 3 Methylated in HCC25; interacts with DNMT3A to reduce methylation cg13794993 0.22 0.38 0.17 6.89E-04 4.15E-04
cg14007067 0.14 0.31 0.17 1.27E-03 8.36E-04
cg06954658 0.16 0.27 0.11 1.47E-03 4.78E-04
cg16433156 0.14 0.25 0.11 1.34E-03 5.46E-04
cg05080154 0.11 0.29 0.18 2.36E-03 9.22E-04
SFRP2 secreted frizzled-related protein 2 Methylated in several cancers, including cervical26; head and neck27, and prostate28 cg22178613 0.16 0.38 0.22 1.10E-03 8.78E-04
ST6GAL2 ST6 beta-galactosamide alpha-2,6-sialyltranferase 2 Upregulated in breast cancer29. Not reported as target of methylation. cg13168617 0.72 0.57 −0.15 1.75E-03 8.25E-04
SCAMP4d Secretory Carrier Membrane Protein 4 Not reported as target of methylation or involved in cancer cg20243900 0.64 0.75 0.11 5.48E-04 2.01E-04
a

CpG number is the unique identifier for the loci provided by Illumina; multiple loci within a differentially methylated region listed in descending order according to genomic position.

b

Difference in median β-value between high and low risk tumors

c

Statistical differences in β-values between the two groups were determined by Mann-Whitney or student's t-test

d

CpG loci located in a genomic sequence that overlaps for ADAT3 and SCAMP4 genes.