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. 2014 Jul;73(7):204–207.

Table 1.

The Gastric Linkage Consortium Criteria for Hereditary Diffuse Gastric Cancer requires Criteria 1 or Criteria 2 to be met before the diagnosis of HDGC.

Gastric Cancer Linkage Consortium Criteria for Hereditary Diffuse Gastric Cancer9,10,16
Criteria 1 Two or more documented cases of diffuse gastric cancer in first or second degree relatives, with at least one diagnosed before the age of 50
Criteria 2 Three or more cases of documented diffuse gastric cancer in first/second degree relatives, independent of age of onset