Table 1.
Reported receptors that bind or mediate the toxicity of soluble amyloid-beta oligomers
Reported receptor | ||
---|---|---|
Amylin receptor [139] |
NMDA receptor [140-144] |
Sortilin [145] |
P53-Bax cell death pathway [146] |
cAMP/PKA/CREB-signaling pathway [147,148] |
Tau protein kinase 1/glycogen synthase kinase-3β [51] |
c-Jun N-terminal kinase [149] |
α-synuclein [150] |
P/Q-type calcium currents [49] |
Cyclin-dependent kinase 5 [149] |
EphB2 [151] |
Dynamin and RhoA [152] |
mGluR, mGluR5, mGluR2 [108,142,149,153,154] |
TNFα [155] |
Cofilin [140] |
p38 mitogen-activated protein kinase [149] |
PrPc[154,156-159] |
Calcineurin [160-162] |
α 7-nicotinic receptors [105] |
AMPA [160] |
Brain-derived neurotrophic factor [131] |
Human LilrB2 [163] |
Insulin receptor [164] |
Sigma 2 receptor [165] |
STI1 [156] |
NMDA, N-methyl-D-aspartate; TNFα, tumor necrosis factor alpha.