Table 7.
Brain areas with reduced GM volume in ALS patients with left limb-onset and corresponding normal controls (P < 0.001, uncorrected).
| Brain anatomical regions |
BA region |
MNI coordinates of peak voxels (mm) |
Cluster size |
T value | P value | ||
|---|---|---|---|---|---|---|---|
| X | Y | Z | |||||
| R_precentral gyri | 4, 6 | 10 | −18 | 48 | 89 | 4.07 | 0.0008 |
| R_superior frontal gyri | 6 | 14 | −2 | 62 | 209 | 3.70 | 0.0008 |
| R_supplementary motor areas | 6 | 12 | −6 | 58 | 28 | 3.42 | 0.0002 |
| R_postcentral gyri | 3 | 36 | −28 | 42 | 33 | 4.09 | 0.0008 |
| R_supramarginal gyri | 40 | 62 | −40 | 22 | 26 | 2.12 | 0.0002 |
| L_precentral gyri | 4, 6 | −34 | −14 | 54 | 111 | 3.56 | 0.0004 |
| L_parietal opercular | −52 | −38 | 20 | 28 | 3.92 | 0.0002 | |
| L_supramarginal gyri | 40 | −54 | −46 | 18 | 93 | 3.42 | 0.0002 |
| L_angular gyri | 39 | −44 | −52 | 12 | 48 | 3.36 | 0.0004 |
L: left; R: right.