Table 2.
Relationship Between Breast Cancer Status and Chronotype or PER3 VNTR Genotype, BRCA GEL Study, Mumbai, India, 2010–2012
| Characteristic | Cases n (%) |
Controls n (%) |
Crude OR (95% CI) |
Adjusted ORa (95% CI) |
|---|---|---|---|---|
| All Women (n=504) | ||||
| PER3 VNTR | ||||
| 4/4 | 85 (37%) | 81 (38%) | 1.0 (Referent) | 1.0 (Referent) |
| 4/5 + 5/5 | 144 (63%) | 131 (62%) | 1.05 (0.71–1.54) | 1.33 (0.83–2.14) |
| Chronotype | ||||
| Morning | 158 (62%) | 151 (61%) | 1.20 (0.69–2.11) | 2.43 (1.23–4.81) |
| No Preference | 27 (11%) | 31 (12%) | 1.0 (Referent) | 1.0 (Referent) |
| Evening | 68 (27%) | 67 (27%) | 1.17 (0.63–2.16) | 2.55 (1.19–5.47) |
| Premenopausal Women (n=259) | ||||
| PER3 VNTR | ||||
| 4/4 | 43 (36%) | 45 (41%) | 1.0 (Referent) | 1.0 (Referent) |
| 4/5 + 5/5 | 75 (64%) | 64 (59%) | 1.23 (0.72–2.09) | 1.43 (0.73–2.81) |
| Chronotype | ||||
| Morning | 75 (57%) | 77 (61%) | 0.75 (0.31–1.81) | 1.54 (0.55–4.29) |
| No Preference | 13 (10%) | 10 (8%) | 1.0 (Referent) | 1.0 (Referent) |
| Evening | 43 (33%) | 40 (32%) | 0.83 (0.33–2.10) | 1.95 (0.65–5.88) |
| Postmenopausal Women (n=245) | ||||
| PER3 VNTR | ||||
| 4/4 | 42 (38%) | 36 (35%) | 1.0 (Referent) | 1.0 (Referent) |
| 4/5 + 5/5 | 69 (62%) | 67 (65%) | 0.88 (0.51–1.54) | 1.31 (0.63–2.73) |
| Chronotype | ||||
| Morning | 83 (68%) | 74 (61%) | 1.68 (0.80–3.55) | 4.51 (1.62–12.58) |
| No Preference | 14 (11%) | 21 (17%) | 1.0 (Referent) | 1.0 (Referent) |
| Evening | 25 (20%) | 27 (22%) | 1.39 (0.58–3.31) | 3.02 (0.92–9.96) |
Analyses adjusted for: age, marital status, tobacco use, family tobacco use, waist-to-hip ratio, walking activity, income, body mass index, and mineral intake. Additional adjustments for Morning/Evening type included: diastolic blood pressure, mosquito repellant use; and for PER3 VNTR: contraceptive use, diastolic blood pressure, consanguinity, vitamin C intake. The 4/5 and 5/5 PER3 VNTR genotypes were combined due to sparse data. Percentages may not equal 100 due to rounding; stratum specific frequencies may not equal total number of cases or controls due to missing data. VNTR: variable number tandem repeat. OR: odds ratio. CI: confidence interval.