Table 2.
Transmission-blocking activities of human polyclonal IgGs fed three days post-infected blood meala
| Sample | Mean oocb | PIm[o]c | p-valued | Mosquitoe | PIp[o]f | p-valueg | Mean Spzh | PIm[s]i |
|---|---|---|---|---|---|---|---|---|
| CS-1 |
30.0 |
1 |
0.93 |
3/20 |
13 |
0.07 |
71.3 |
-184 |
| |
(0, 75) |
(-148, 62) |
|
|
(-1, 35) |
|
|
|
| CS-2 |
29.9 |
1 |
0.92 |
0/20 |
-3 |
0.48 |
49.4 |
-97 |
| |
(2, 56) |
(-139, 62) |
|
|
(-15, 14) |
|
|
|
| CS-3 |
37.6 |
-24 |
0.66 |
0/20 |
-3 |
0.48 |
56.9 |
-127 |
| |
(5, 69) |
(-190, 51) |
|
|
(-15, 14) |
|
|
|
| CS-4 |
34.5 |
-14 |
0.88 |
3/20 |
13 |
0.07 |
35.4 |
-41 |
| |
(0, 87) |
(-175, 57) |
|
|
(-1, 35) |
|
|
|
| Contl-1 |
25.5 |
N/A |
N/A |
0/20 |
N/A |
N/A |
43.1 |
N/A |
| |
(1, 80) |
|
|
|
|
|
|
|
| Contl-2 |
35.0 |
N/A |
N/A |
1/20 |
N/A |
N/A |
7.0 |
N/A |
| (0, 83) |
aAll purified IgGs were tested at 3.75 mg/ml and fed three days post-infected blood meal.
bArithmetic mean (range) of oocysts per mosquito midgut.
cPer cent inhibition of mean oocyst intensity (PIm[o]) and the 95% confidence interval (95% CI).
dTwo-sided p-values for testing whether PIm[o] is significantly different from 0.
eNumber of mosquitoes without any oocysts/number of mosquitoes examined.
fPer cent inhibition of prevalence of mosquitoes with oocysts (PIp[o]) and the 95% CI.
gp-values of PIp[o].
hNumber of sporozoites (×103) per mosquito calculated from a pool of salivary glands of 12 mosquitoes.
iPer cent inhibition of mean sporozoite intensity (PIm[s]) calculated with the average of sporozoites counts of Contl-1 and Contl-2.