Table 3.
Transmission-blocking activities of human polyclonal IgGs fed six days post-infected blood meala
| Sample | Mean oocb | PIm[o]c | p-valued | Mosquitoe | PIp[o]f | p-valueg | Mean Spzh | PIm[s]i |
|---|---|---|---|---|---|---|---|---|
| CS-1 |
37.7 |
-13 |
0.82 |
0/20 |
0 |
1.00 |
91.1 |
-2 |
| |
(19, 82) |
(-176, 54) |
|
|
(-10, 16) |
|
|
|
| CS-2 |
33.7 |
-1 |
0.97 |
1/20 |
5 |
0.15 |
72.7 |
19 |
| |
(0, 54) |
(-151, 63) |
|
|
(-4, 24) |
|
|
|
| CS-3 |
35.8 |
-8 |
0.94 |
0/20 |
0 |
1.00 |
87.4 |
3 |
| |
(5, 72) |
(-157, 59) |
|
|
(-10, 16) |
|
|
|
| CS-4 |
34.6 |
-4 |
0.98 |
0/20 |
0 |
1.00 |
83.8 |
7 |
| |
(6, 74) |
(-144, 61) |
|
|
(-10, 16) |
|
|
|
| Contl-1 |
33.2 |
N/A |
N/A |
0/20 |
N/A |
N/A |
84.8 |
N/A |
| |
(10, 62) |
|
|
|
|
|
|
|
| Contl-2 |
33.3 |
N/A |
N/A |
0/20 |
N/A |
N/A |
94.7 |
N/A |
| (10, 77) |
aAll purified IgGs were tested at 3.75 mg/ml and fed six days post-infected blood meal.
bArithmetic mean (range) of oocysts per mosquito midgut.
cPer cent inhibition of mean oocyst intensity (PIm[o]) and the 95% confidence interval (95% CI).
dTwo-sided p-values for testing whether PIm[o] is significantly different from 0.
eNumber of mosquitoes without any oocysts/number of mosquitoes examined.
fPer cent inhibition of prevalence of mosquitoes with oocysts (PIp[o]) and the 95% CI.
gp-values of PIp[o].
hNumber of sporozoites (×103) per mosquito calculated from a pool of salivary glands of 12 mosquitoes.
iPer cent inhibition of mean sporozoite intensity (PIm[s]) calculated with the average of sporozoites counts of Contl-1 and Contl-2.