Table 4.
Transmission-blocking activities of human mAb fed with infected blood meala
| Sample | Mean oocb | PIm[o]c | p-valued | Mosquitoe | PIp[o]f | p-valueg | Mean Spzh | PIm[s]i | p-valuej |
|---|---|---|---|---|---|---|---|---|---|
| First experiment | |||||||||
| MAL1C |
18.8 |
3 |
0.94 |
3/20 |
11 |
0.29 |
37.9 |
-21 |
0.72 |
| |
(0, 55) |
(-191, 67) |
|
|
(-14, 33) |
|
(0, 94.0) |
(-254, 58) |
|
| MAL2A |
7.5 |
61 |
0.09 |
7/20 |
32 |
0.02 |
39.0 |
-24 |
0.63 |
| |
(0, 37) |
(-24, 87) |
|
|
(7, 55) |
|
(0.5, 89.0) |
(-215, 51) |
|
| Contl |
19.5 |
N/A |
N/A |
1/20 |
N/A |
N/A |
31.2 |
N/A |
N/A |
| |
(0, 36) |
|
|
|
|
|
(0, 146.5) |
|
|
| Second experiment | |||||||||
| MAL1C |
33.8 |
-21 |
0.71 |
0/20 |
0 |
1.000 |
N.D. |
N.D. |
N.D. |
| |
(12, 59) |
(-248, 56) |
|
|
(-19, 16) |
|
|
|
|
| MAL2A |
42.2 |
-51 |
0.46 |
0/20 |
0 |
1.000 |
N.D. |
N.D. |
N.D. |
| |
(13, 71) |
(-344, 49) |
|
|
(-19, 16) |
|
|
|
|
| Contl |
27.9 |
N/A |
N/A |
0/20 |
N/A |
N/A |
N.D. |
N.D. |
N.D. |
| (1, 55) | |||||||||
aAll mAb were tested at 0.231 mg/ml and fed with infected blood meal at the same time.
bArithmetic mean (range) of oocysts per mosquito midgut.
cPer cent inhibition of mean oocyst intensity (PIm[o]) and the 95% confidence interval (95% CI).
dTwo-sided p-values for testing whether PIm[o] is significantly different from 0.
eNumber of mosquitoes without any oocysts/number of mosquitoes examined.
fPer cent inhibition of prevalence of mosquitoes with oocysts (PIp[o]) and the 95% CI.
gp-values of PIp[o].
hArithmetic mean (range) of sporozoites (×103) per mosquito. No sporozoite count in the second experiment.
iPer cent inhibition of mean sporozoite intensity (PIm[s]) and the 95% CI.
jp-values of PIm[s].