Table 5.
Transmission-blocking activities of human mAb fed three days post-infected blood meala
| Sample | Mean oocb | PIm[o]c | p-valued | Mosquitoe | PIp[o]f | p-valueg | Mean Spzh | PIm[s]i |
|---|---|---|---|---|---|---|---|---|
| MAL1C |
15.1 |
2 |
0.97 |
1/20 |
-27 |
0.08 |
9.0 |
53 |
| |
(0, 36) |
(-185, 65) |
|
|
(-80, 3) |
|
|
|
| MAL2A |
11.6 |
24 |
0.64 |
1/20 |
-27 |
0.08 |
19.8 |
-4 |
| |
(0, 30) |
(-119, 74) |
|
|
(-80, 3) |
|
|
|
| Contl |
15.3 |
N/A |
N/A |
5/20 |
N/A |
N/A |
19.0 |
N/A |
| (0, 44) |
aAll mAb were tested at 0.231 mg/ml and fed three days post-infected blood meal.
bArithmetic mean (range) of oocysts per mosquito midgut.
cPer cent inhibition of mean oocyst intensity (PIm[o]) and the 95% confidence interval (95% CI).
dTwo-sided p-values for testing whether PIm[o] is significantly different from 0.
eNumber of mosquitoes without any oocysts/number of mosquitoes examined.
fPer cent inhibition of prevalence of mosquitoes with oocysts (PIp[o]) and the 95% CI.
gp-values of PIp[o].
hNumber of sporozoites (×103) per mosquito calculated from a pool of salivary glands of 12 mosquitoes.
iPer cent inhibition of mean sporozoite intensity (PIm[s]).