Figure 2.

Comparison of interactions detected by T2C for the human chr11p15.5 region with Hi-C and 4C-seq. (A) Hi-C data generated by Dixon et al. for IMR90 cells covering the H19/IGF2 region of interest, presented at a resolution 40 kbp with their respective domain boundaries (DB) depicted as black boxes [1]. (B) T2C interactions in HB2 cells at a 40 kbp resolution. The overall topological domain pattern observed by the two methods is similar (r_s = 0.64, P <2.2 × 10^-16). (C) T2C interaction with their actual resolution at restriction fragment level. (D) Interactions detected by 3C [33]. The restriction fragments are indicated with yellow triangles. (E) 4C-seq interaction data [14], for a viewpoint close to the IGF2 gene. (F) Interactions observed for a particular viewpoint by T2C plotted with logarithmic y-axis. The position of the viewpoint is indicated as bold pink line to allow a direct comparison between the methods. The thin pink lines indicate a couple of interaction fragments for ease of comparison.