Table 1.

Patient Characteristics and Treatment of Actinomycosis

Patient	Age, years	Sex	Genotype	Age at diagnosis	Site of actinomycosis	Therapya	Surgery	Outcome
1	23	M	gp91phox	7 years	Cervical/submandibular lymph nodes	Intravenous ceftriaxone-meropenem, penicillin V, BMT	Yes	Survived, no recurrence
2	6	M	gp91phox	2 years	Cervical lymph node	Oral amoxicillin-azithromycin-clindamycin	Yes	Survived, no recurrence
3	28	F	p22phox	6 months	Cervical lymph node, lung/liver abscess	Intravenous penicillin G, oral azithromycin	RFA	Survived, no recurrence
4	19	F	gp91phox	12 years	Cervical lymph nodes	Intravenous vancomycin-imipenem-clindamycin, oral clindamy- cinintravenous penicillin G	Yes	Survived, no recurrence
5	13	M	gp91phox	6 weeks	Cervical lymph node	Intravenous meropenem	Yes	Survived, no recurrence
6	10	M	gp91phox	7 years	Liver	Granulocyte transfusions, oral amoxi-cillin-clarithromycin, corticosteroids, intravenous amoxicillin-clindamy-cin, azithromycin	Yes	Survived, recurrence
7	16	M	gp91phox	1 year	Liver	Ultrasonography-guided drainage, in- terferon-g, intravenous penicillin G, penicillin V	Yes	Survived, no recurrence
8	38	M	gp91phox	6 years	Liver	Oral amoxicillin, intravenous tri-methoprim-sulfamethoxazole, intravenous voriconazole	RFA	Survived, recurrence
9	10	M	p22phox	1 year	Lung, cervical lymph node	BMT, granulocyte transfusions, 5-flucytosine, interferon gamma	No	Survived, no recurrence
10	2	M	gp91phox	8 months	Lung, cervical lymph node	Intravenous clindamy cin-minocycline-ciprofloxacin, oral minocycline-cipro-floxacin, intravenous ceftriaxone-teicoplanin, oral penicillin-trovafloxacin	Yes	Recurrence, died

NOTE. BMT, bone marrow transplantation; RFA, radiofrequency ablation.

^aItems in boldface type indicate that the antibiotic therapy was apparently effective against infection with Actinomyces species.